Amyloid-beta (Aß) and hyperphosphorylated tau are hallmark lesions of Alzheimer's disease
(AD). However, the loss of synapses and dysfunctions of neurotransmission are more …

The plasma membrane of eukaryotic cells contains several types of lipids displaying high
biochemical variability in both their apolar moiety (eg, the acyl chain of glycerolipids) and …

Biological membranes show lateral and transverse asymmetric lipid distribution. Cholesterol
(Chol) localizes in both hemilayers, but in the external one it is mostly condensed in lipid …

Cognitive dysfunction is one of the most typical characteristics in various neurodegenerative
diseases such as Alzheimer's disease and Parkinson's disease (advanced stage). Although …

Cholesterol influences ion-channel function, distribution and clustering in the membrane,
endocytosis and exocytic sorting of the nicotinic acetylcholine receptor (AChR). We report …

Lipid rafts are membrane domains, more ordered than the bulk membrane and enriched in
cholesterol and sphingolipids. They represent a platform for protein-lipid and protein–protein …

The cholinergic system plays an essential role in brain development, physiology, and
pathophysiology. Herein, we review how specific alterations in this system, through genetic …

Alzheimer disease (AD) is the most prevalent form of dementia among elderly people.
Owing to its varied and multicausal etiopathology, intervention strategies have been highly …

The idea that multi-scale dynamic complex systems formed by interacting macromolecules
and metabolites, cells, organs and organisms underlie some of the most fundamental …

The nicotinic acetylcholine receptor (nAChR) is a transmembrane protein that mediates fast
intercellular communication in response to the endogenous neurotransmitter acetylcholine …