Heart disease is the leading cause of death worldwide and imposes a significant burden on
healthcare systems globally. A major hurdle to the development of more effective …

Despite numerous advances in treatments for cardiovascular disease, heart failure (HF)
remains the leading cause of death worldwide. A significant factor contributing to the …

Cardiovascular diseases are caused by hereditary factors, environmental conditions, and
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …

Recently, an increasing number of studies have demonstrated that induced pluripotent stem
cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine …

Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but
also contributes to the high morbidity and mortality rates of cardiovascular diseases …

Optical map** is a powerful imaging technique widely adopted to measure membrane
potential changes and intracellular Ca2+ variations in excitable tissues using voltage …

Utilizing recent advances in human induced pluripotent stem cell (hiPSC) technology,
nonlinear analysis and machine learning we can create novel tools to evaluate drug …

Identification of early biomarkers of heart injury and drug-induced cardiotoxicity is important
to eliminate harmful drug candidates early in preclinical development and to prevent severe …

Human induced pluripotent stem cells (hiPSCs) can be used to generate various cell types
in the human body. Hence, hiPSC-derived cardiomyocytes (hiPSC-CMs) represent a …

Cardiovascular diseases are the leading cause of death worldwide. Several strategies–
small molecules, gene therapy, surgeries, cardiac rehabilitation–have been developed to …