Biomaterial central infection (BCI) is a tough problem that has attracted high attention. The
most common source of infection in biomaterial centers is bacterial infections. For the past …

Biomaterial-associated infections (BAIs) are an increasing problem where antibiotic
therapies are often ineffective. The design of novel strategies to prevent or combat infection …

Persistent bacteria, such as intracellular and biofilm bacteria, are critical challenges in clinic
treatment because they are refractory to antibiotics management under the shelter of …

Robust bacterial metabolism and the immunosuppression on peripheral immune cells cause
biofilm‐associated infections (BAIs) extremely refractory to be eradicated via antibiotics …

Recently, the major challenge in treating osteosarcoma patients is the metastatic disease,
most commonly in the lungs. However, the underlying mechanism of recurrence and …

Severe traumatic injuries are a widespread and challenging clinical problem, and yet the
factors that drive successful healing and restoration of function are still not well understood …

The number of orthopedic implants for bone fixation and joint arthroplasty has been steadily
increasing over the past few years. However, implant-associated infection (IAI), a major …

The lack of site-specific chemotherapeutic agents to treat bone malignancy throws a
significant challenge in the design of a delivery vehicle. The major scientific question posed …

Bone is a complex organic–inorganic composite tissue composed of∼ 30% organics and∼
70% hydroxyapatite (HAp). Inspired by this, we used 30% collagen and 70% HAp extracted …

Antibiotic loaded bone cements are widely used in total joint replacement (TJR); despite
many limitations such as a burst release which leads to antibiotic concentration below …