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Transforming the understanding of brain immunity
Contemporary studies have completely changed the view of brain immunity from envisioning
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
the brain as isolated and inaccessible to peripheral immune cells to an organ in close …
Brain regulatory T cells
The brain, long thought to be isolated from the peripheral immune system, is increasingly
recognized to be integrated into a systemic immunological network. These conduits of …
recognized to be integrated into a systemic immunological network. These conduits of …
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain
N Rachmian, S Medina, U Cherqui, H Akiva… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …
contributing factors, including brain inflammation. Microglia, and specifically those …
Blood and CSF chemokines in Alzheimer's disease and mild cognitive impairment: a systematic review and meta-analysis
F Zhou, Y Sun, X ** all options open
R Arfaei, N Mikaeili, F Daj, A Boroumand… - International …, 2024 - Elsevier
Abstract Alzheimer's disease (AD), as a neurodegenerative disorder, distresses the elderly
in large numbers and is characterized by β-amyloid (Aβ) accumulation, elevated tau protein …
in large numbers and is characterized by β-amyloid (Aβ) accumulation, elevated tau protein …
PD-L1/PD-1 pathway: a potential neuroimmune target for pain relief
D Deng, T Zhang, L Ma, W Zhao, S Huang, K Wang… - Cell & Bioscience, 2024 - Springer
Pain is a common symptom of many diseases with a high incidence rate. Clinically, drug
treatment, as the main method to relieve pain at present, is often accompanied by different …
treatment, as the main method to relieve pain at present, is often accompanied by different …
The synergistic potential of combining PD-1/PD-L1 immune checkpoint inhibitors with NOD2 agonists in Alzheimer's disease treatment
M Ghareghani, S Rivest - International Journal of Molecular Sciences, 2023 - mdpi.com
Our research over the past decade has compellingly demonstrated the potential of
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) receptor agonists …
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) receptor agonists …