[HTML][HTML] Tracking an elusive killer: state of the art of molecular-genetic knowledge and laboratory role in diagnosis and risk stratification of thoracic aortic aneurysm …

R De Cario, M Giannini, G Cassioli, A Kura, AM Gori… - Diagnostics, 2022 - mdpi.com
The main challenge in diagnosing and managing thoracic aortic aneurysm and dissection
(TAA/D) is represented by the early detection of a disease that is both deadly and “elusive” …

TGFβ-2 haploinsufficiency causes early death in mice with Marfan syndrome

N Sachan, CKL Phoon, L Zilberberg, MC Kugler, T Ene… - Matrix Biology, 2023 - Elsevier
To assess the contribution of individual TGF-β isoforms to aortopathy in Marfan syndrome
(MFS), we quantified the survival and phenotypes of mice with a combined fibrillin1 (the …

TGF-β2 enhances nanoscale cortex stiffness via condensation of cytoskeleton-focal adhesion plaque

M Duan, Y Liu, C Pi, Y Zhao, Y Tian, J **e - Biophysical Journal, 2025 - cell.com
Physical spatiotemporal characteristics of cellular cortex dominate cell functions and even
determine cell fate. The cellular cortex is able to reorganize to a dynamic steady status with …

Investigating the Impact of Endothelial Dysfunction and Aging on Vascular Remodeling Using Mouse Models

L Du - 2022 - search.proquest.com
Endothelial dysfunction, characterized by a reduction in the bioavailability of nitric oxide
(NO), is a major factor in the initiation and progression of atherosclerosis, an age-related …

An in Vitro Approach to Vascular Therapeutic Testing

SA Hasanain - 2021 - search.proquest.com
Aortopathies refer to a broad class of pathological conditions affecting the aorta and are a
major cause of morbidity and mortality in the US. Specifically, aortic aneurysms and aortic …

An in Vitro Approach To Vascular Therapeutic Testing

S Ali Hasanain - 2021 - scholarcommons.sc.edu
Aortopathies refer to a broad class of pathological conditions affecting the aorta and are a
major cause of morbidity and mortality in the US. Specifically, aortic aneurysms and aortic …