HIV infection can be effectively treated by lifelong administration of combination antiretroviral
therapy, but an effective vaccine will likely be required to end the HIV epidemic. Although the …

The genotype–fitness map (that is, the fitness landscape) is a key determinant of evolution,
yet it has mostly been used as a superficial metaphor because we know little about its …

The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel
coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). There is an …

Microbial consortia exhibit complex functional properties in contexts ranging from soils to
bioreactors to human hosts. Understanding how community composition determines …

Inverse problems in statistical physics are motivated by the challenges of 'big data'in
different fields, in particular high-throughput experiments in biology. In inverse problems, the …

The emergence of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-
CoV-2) is a major concern given their potential impact on the transmissibility and …

The quantitative characterization of mutational landscapes is a task of outstanding
importance in evolutionary and medical biology: It is, for example, of central importance for …

The fight against cancer has drawn researchers from a wide variety of disciplines, ranging
from molecular biology to physics, but the perspective of an ecological theorist has been …

In many branches of materials science it is now routine to generate data sets of such large
size and dimensionality that conventional methods of analysis fail. Paradigms and tools from …

Increasing evidence suggests that durable drug-free control of HIV-1 replication is enabled
by effective cellular immune responses that may induce an attenuated viral reservoir …