Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
Stress, epigenetics, and aging: unraveling the intricate crosstalk
Aging, as a complex process involving multiple cellular and molecular pathways, is known to
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
be exacerbated by various stresses. Because responses to these stresses, such as oxidative …
Human age reversal: Fact or fiction?
Although chronological age correlates with various age‐related diseases and conditions, it
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
does not adequately reflect an individual's functional capacity, well‐being, or mortality risk …
[HTML][HTML] An Evidence-Based Narrative Review of Mechanisms of Resistance Exercise–Induced Human Skeletal Muscle Hypertrophy
Skeletal muscle plays a critical role in physical function and metabolic health. Muscle is a
highly adaptable tissue that responds to resistance exercise (RE; loading) by …
highly adaptable tissue that responds to resistance exercise (RE; loading) by …
A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body
Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …
to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and …
[HTML][HTML] Advancing personalized medicine in neurodegenerative diseases: The role of epigenetics and pharmacoepigenomics in pharmacotherapy
About 80% of brain disorders have a genetic basis. The pathogenesis of most
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …
neurodegenerative diseases is associated with a myriad of genetic defects, epigenetic …
Skeletal muscle memory
Skeletal muscle memory is an exciting phenomenon gaining significant traction across
several scientific communities, among exercise practitioners, and the public. Research has …
several scientific communities, among exercise practitioners, and the public. Research has …
Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle
Exercise training prevents age‐related decline in muscle function. Targeting epigenetic
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …
aging is a promising actionable mechanism and late‐life exercise mitigates epigenetic aging …
Muscle-specific cellular and molecular adaptations to late-life voluntary concurrent exercise
Murine exercise models can provide information on factors that influence muscle
adaptability with aging, but few translatable solutions exist. Progressive weighted wheel …
adaptability with aging, but few translatable solutions exist. Progressive weighted wheel …
A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle
Exercise promotes functional improvements in aged tissues, but the extent to which it
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …
simulates partial molecular reprogramming is unknown. Using transcriptome profiling from …