Rationale The chronic mild stress (CMS) paradigm was first described almost 40 years ago
and has become a widely used model in the search for antidepressant drugs for major …

Panax notoginseng (Burk) FH Chen, as traditional Chinese medicine, has a long history of
high clinical value, such as anti-inflammatory, anti-oxidation, inhibition of platelet …

Early‐life stress increases the prevalence of psychiatric diseases associated with emotional
dysregulation. Emotional regulation requires the inhibitory influence of the medial prefrontal …

Zebrafish are increasingly being utilized to model the behavioral and neurochemical effects
of pharmaceuticals and, more recently, pharmaceutical interactions. Zebrafish models of …

Ethnopharmacological relevance **aochaihutang (XCHT) has been used in China for
thousands of years to treat “Shaoyang syndrome”, which involves depressive-like symptoms …

Depression is frequently associated with inflammation. Animal studies have shown that
peripheral inflammation induces depressive-like behaviour, but the underlying mechanisms …

Caffeine is a substance present in several foods and drinks of common western diet.
Although high caffeine concentrations induce anxiogenic properties in various species, the …

Background Depression is a chronic and recurrent syndrome of mood disorder causing
immense social and economic burden; thus, treatment should be improved. Guanxin …

Angelica sinensis (AS), a traditional Chinese herbal medicine, has pharmaceutical effects
on menstrual illness, cerebrovascular diseases, cardiovascular diseases, and cognitive …

Major depressive disorder (MDD) is the foremost cause of global disability, being
responsible for enormous personal, societal, and economical costs. Importantly, existing …