In the contexts of aging, injury, or neuroinflammation, activated microglia signaling with TNF-
α, IL-1α, and C1q induces a neurotoxic astrocytic phenotype, classified as A1, A1-like, or …

Magnesium (Mg) is involved in the regulation of metabolism and in the maintenance of the
homeostasis of all the tissues, including the brain, where it harmonizes nerve signal …

Background: The excess production of reactive oxygen species (ROS) after traumatic spinal
cord injury (TSCI) has been identified as a leading cause of secondary injury, which can …

A major therapeutic goal in the treatment of multiple sclerosis (MS) is to prevent the
accumulation of disability over an often decades-long disease course. Disability progression …

Most age-related neurodegenerative diseases remain incurable owing to an incomplete
understanding of the disease mechanisms. Several environmental and genetic factors …

Chronic inflammation of white adipose tissue is a key link between obesity and the
associated metabolic syndrome. Transient receptor potential melastatin-like 7 (TRPM7) is …

Glial cell polarization plays a pivotal role in various neurological disorders. In response to
distinct stimuli, glial cells undergo polarization to either mitigate neurotoxicity or facilitate …

Multiple Sclerosis (MS) is a demyelinating disease of the human central nervous system
having an unconfirmed pathoetiology. Although animal models are used to mimic the …

Today, neurodegenerative disorders like Alzheimer's disease (AD), Parkinson's disease
(PD), frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) affect millions …

Metal homeostasis is critical to normal neurophysiological activity. Metal ions are involved in
the development, metabolism, redox and neurotransmitter transmission of the central …