[HTML][HTML] Alzheimer's disease pathophysiology in the retina
The retina is an emerging CNS target for potential noninvasive diagnosis and tracking of
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Alzheimer's disease (AD). Studies have identified the pathological hallmarks of AD …
Alzheimer's retinopathy: seeing disease in the eyes
The neurosensory retina emerges as a prominent site of Alzheimer's disease (AD)
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …
pathology. As a CNS extension of the brain, the neuro retina is easily accessible for …
Retinal electrophysiology in central nervous system disorders. A review of human and mouse studies
The retina and brain share similar neurochemistry and neurodevelopmental origins, with the
retina, often viewed as a “window to the brain.” With retinal measures of structure and …
retina, often viewed as a “window to the brain.” With retinal measures of structure and …
Early visual alterations in individuals at-risk of Alzheimer's disease: A multidisciplinary approach
Background The earliest pathological features of Alzheimer's disease (AD) appear decades
before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal …
before the clinical symptoms. The pathology affects the brain and the eye, leading to retinal …
Retinal dysfunction in Alzheimer's disease and implications for biomarkers
C Liao, J Xu, Y Chen, NY Ip - Biomolecules, 2021 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that manifests as
cognitive deficits and memory decline, especially in old age. Several biomarkers have been …
cognitive deficits and memory decline, especially in old age. Several biomarkers have been …
Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer's …
V Latina, G Giacovazzo, F Cordella… - Acta Neuropathologica …, 2021 - Springer
Retina and optic nerve are sites of extra-cerebral manifestations of Alzheimer's Disease
(AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein …
(AD). Amyloid-β (Aβ) plaques and neurofibrillary tangles of hyperphosphorylated tau protein …
Disturbed circadian rhythm and retinal degeneration in a mouse model of Alzheimer's disease
The circadian clock is synchronized to the 24 h day by environmental light which is
transmitted from the retina to the suprachiasmatic nucleus (SCN) primarily via the …
transmitted from the retina to the suprachiasmatic nucleus (SCN) primarily via the …
[HTML][HTML] Circadian rhythm disruption and retinal dysfunction: a bidirectional link in Alzheimer's disease?
L Carrero, D Antequera, C Municio… - Neural Regeneration …, 2024 - journals.lww.com
Dysfunction in circadian rhythms is a common occurrence in patients with Alzheimer's
disease. A predominant function of the retina is circadian synchronization, carrying …
disease. A predominant function of the retina is circadian synchronization, carrying …
A multi-regression framework to improve diagnostic ability of optical coherence tomography retinal biomarkers to discriminate mild cognitive impairment and …
Background Diagnostic performance of optical coherence tomography (OCT) to detect
Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains limited. We …
Alzheimer's disease (AD) and mild cognitive impairment (MCI) remains limited. We …
Subsequent and simultaneous electrophysiological investigation of the retina and the visual cortex in neurodegenerative and psychiatric diseases: what are the …
K Tursini, I Remy, S Le Cam, V Louis-Dorr… - Frontiers in …, 2023 - frontiersin.org
Visual electrophysiological deficits have been reported in neurodegenerative disorders as
well as in mental disorders. Such alterations have been mentioned in both the retina and the …
well as in mental disorders. Such alterations have been mentioned in both the retina and the …