Notch signaling is an evolutionarily highly conserved signaling mechanism, but in contrast to
signaling pathways such as Wnt, Sonic Hedgehog, and BMP/TGF-β, Notch signaling occurs …

Breast cancer is the most common form of cancer diagnosed in women worldwide and the
second leading cause of cancer-related deaths in the USA. Despite the development of …

Simple Summary Presently, the investigation of the tumor is carried out using different
models. One of the promising areas is the creation of 3D tumor models, such as spheroids …

Direct inhibition of transcription factor complexes remains a central challenge in the
discipline of ligand discovery. In general, these proteins lack surface involutions suitable for …

Alzheimer disease is characterized by the accumulation of abnormally folded protein
fragments, ie, amyloid beta peptide (Aβ) and tau that precipitate in amyloid plaques and …

The Notch signaling pathway is evolutionarily conserved and responsible for cell fate
determination in the develo** embryo and mature tissue. At the molecular level, ligand …

Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-
like properties. Immunohistochemical staining of a large panel of primary non–small cell …

Purpose Aberrant Notch signaling has been implicated in the pathogenesis of many human
cancers. MK-0752 is a potent, oral inhibitor of γ-secretase, an enzyme required for Notch …

Notch signaling regulates cell specification and homeostasis of stem cell compartments, and
it is counteracted by the cell fate determinant Numb. Both Numb and Notch have been …

Through epithelial-mesenchymal transition (EMT), cancer cells acquire enhanced ability of
migration and invasion, stem cell like characteristics and therapeutic resistance. Notch …