Gap junctions are essential to the function of multicellular animals, which require a high
degree of coordination between cells. In vertebrates, gap junctions comprise connexins and …

Connexins are ubiquitous channel forming proteins that assemble as plasma membrane
hemichannels and as intercellular gap junction channels that directly connect cells. In the …

Connexins are a family of transmembrane proteins that play a key role in cardiac physiology.
Gap junctional channels put into contact the cytoplasms of connected cardiomyocytes …

The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal
bone homeostasis and the clinical field of bone regeneration. The latter makes use of …

Abstract The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered
the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular …

Reperfusion may induce additional cell death in patients with acute myocardial infarction
receiving primary angioplasty or thrombolysis. Altered intracellular Ca2+ handling was …

Cxs (connexins), the protein subunits forming gap junction intercellular communication
channels, are transported to the plasma membrane after oligomerizing into hexameric …

The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major
portal for the release of factors responsible for the anabolic effects of mechanical loading on …

Although often overshadowed by factors influencing seizure initiation, seizure termination is
a critical step in the return to the interictal state. Understanding the mechanisms contributing …

Plasma membrane hemichannels composed of connexin (Cx) proteins are essential
components of gap junction channels but accumulating evidence suggests functions of …