Streamlining RNA Aptamer Selection via Unique Molecular Identifiers and High-Throughput Sequencing

D Zhang, Y Liu, H Huang, T Fu, T Bing, X Wu… - Analytical …, 2024 - ACS Publications
Aptamers are valuable tools for applications such as cell imaging, drug delivery, and
therapeutics. RNA aptamers, in particular, exhibit complex structural diversity and flexibility …

Probing three-dimensional cyclooctatetraene as nucleobase modification in aptamer selection

GC Dahm, U Akhtar, A Bouvier-Müller, L Lim… - 2025 - chemrxiv.org
Decoration of aptamers with chemical modifications at the level of nucleobases grants
access to alternative binding modes which often result in improved binding properties. Most …