Aerobic exercise and scaffolds with hierarchical porosity synergistically promote functional recovery post volumetric muscle loss

Y Endo, M Samandari, M Karvar, A Mostafavi, J Quint… - Biomaterials, 2023 - Elsevier
Volumetric muscle loss (VML), which refers to a composite skeletal muscle defect, most
commonly heals by scarring and minimal muscle regeneration but substantial fibrosis …

Deletion of SA β‐Gal+ cells using senolytics improves muscle regeneration in old mice

CM Dungan, KA Murach, CJ Zdunek, ZJ Tang… - Aging …, 2022 - Wiley Online Library
Systemic deletion of senescent cells leads to robust improvements in cognitive,
cardiovascular, and whole‐body metabolism, but their role in tissue reparative processes is …

The role of hypoxia and hypoxia signaling in skeletal muscle physiology

Y Endo, C Zhu, E Giunta, C Guo, DJ Koh… - Advanced …, 2024 - Wiley Online Library
Hypoxia and hypoxia signaling play an integral role in regulating skeletal muscle
physiology. Environmental hypoxia and tissue hypoxia in muscles cue for their appropriate …

Maladaptive immune activation in age-related decline of muscle function

M Montano, R Correa-de-Araujo - The Journals of Gerontology …, 2023 - academic.oup.com
Age-related changes in immune competency and inflammation play a role in the decline of
physical function. In this review of the conference on Function-Promoting Therapies held in …

VEGFA promotes skeletal muscle regeneration in aging

Y Endo, CD Hwang, Y Zhang, S Olumi… - Advanced …, 2023 - Wiley Online Library
Aging is associated with loss of skeletal muscle regeneration. Differentially regulated
vascular endothelial growth factor (VEGF) A with aging may partially underlies this loss of …

[HTML][HTML] Exercise-induced gene expression changes in skeletal muscle of old mice

Y Endo, Y Zhang, S Olumi, M Karvar, S Argawal… - Genomics, 2021 - Elsevier
Exercise is believed to be beneficial for skeletal muscle functions across all ages.
Regimented exercise is often prescribed as an effective treatment/prophylaxis for age …

Inhibition of p53-MDM2 binding reduces senescent cell abundance and improves the adaptive responses of skeletal muscle from aged mice

GL Nolt, AR Keeble, Y Wen, AC Strong, NT Thomas… - GeroScience, 2024 - Springer
Skeletal muscle adaptation to external stimuli, such as regeneration following injury and
hypertrophy in response to resistance exercise, are blunted with advanced age. The …

Li**g-Anfei Decoction Attenuates COPD in a Mouse Model: Network Pharmacology Analysis, Molecular Docking, and Experimental Validation

J Zhu, J Liu, W Jia, G Shao… - Pharmacognosy …, 2024 - journals.sagepub.com
Background Today, network pharmacology and molecular docking were utilized for
investigation and prediction of possible mechanisms in fields such as pharmacognosy and …

Polymorphism, Expression, and Structure Analysis of a Key Gene ARNT in Sheep (Ovis aries)

X Wang, J Bao, Y Bi, W Hu, L Zhang - Biology, 2022 - mdpi.com
Simple Summary Although the fact that ARNT may be related to sheep embryonic muscle
growth and development has been clearly shown by our prior TMT proteomic study, its …

Muscle Cryoinjury and Quantification of Regenerating Myofibers in Mice

Y Endo, M Karvar, I Sinha - Bio-protocol, 2021 - bio-protocol.org
Cryoinjury, or injury due to freezing, is a method of creating reproducible, local injuries in
skeletal muscle. This method allows studying the regenerative response following muscle …