Therapeutic cancer vaccines: advancements, challenges and prospects

T Fan, M Zhang, J Yang, Z Zhu, W Cao… - Signal Transduction and …, 2023 - nature.com
With the development and regulatory approval of immune checkpoint inhibitors and adoptive
cell therapies, cancer immunotherapy has undergone a profound transformation over the …

Biomaterials facilitating dendritic cell‐mediated cancer immunotherapy

H Dong, Q Li, Y Zhang, M Ding, Z Teng… - Advanced …, 2023 - Wiley Online Library
Dendritic cell (DC)‐based cancer immunotherapy has exhibited remarkable clinical
prospects because DCs play a central role in initiating and regulating adaptive immune …

Supramolecular Lipid Nanoparticles Based on Host–Guest Recognition: A New Generation Delivery System of mRNA Vaccines For Cancer Immunotherapy

S Qi, X Zhang, X Yu, L **, K Yang, Y Wang… - Advanced …, 2024 - Wiley Online Library
Dendritic cell (DC) maturation is a crucial process for antigen presentation and the initiation
of T cell‐mediated immune responses. Toll‐like receptors play pivotal roles in stimulating …

Dendritic nanomedicine with boronate bonds for augmented chemo‐immunotherapy via synergistic modulation of tumor immune microenvironment

Y Li, Y Wu, Z Fang, Y Zhang, H Ding, L Ren… - Advanced …, 2024 - Wiley Online Library
Unsatisfied tumor accumulation of chemotherapeutic drugs and a complicated
immunosuppressive microenvironment diminish the immune response rate and the …

Engineered living materials for advanced diseases therapy

X Dong, W Wu, P Pan, XZ Zhang - Advanced Materials, 2023 - Wiley Online Library
Natural living materials serving as biotherapeutics exhibit great potential for treating various
diseases owing to their immunoactivity, tissue targeting, and other biological activities. In this …

Anti-tumor immune potentiation targets-engineered nanobiotechnologies: design principles and applications

R Jiao, X Lin, Q Zhang, Y Zhang, W Qin, Q Yang… - Progress in Materials …, 2024 - Elsevier
Combined therapeutic strategies hold promises in augmenting antigen release to enhance
anti-tumor immunity, which have garnered attention in numerous scholarly reviews. Beyond …

The quest for nanoparticle-powered vaccines in cancer immunotherapy

Z Sun, H Zhao, L Ma, Y Shi, M Ji, X Sun, D Ma… - Journal of …, 2024 - Springer
Despite recent advancements in cancer treatment, this disease still poses a serious threat to
public health. Vaccines play an important role in preventing illness by preparing the body's …

Engineering metal-based hydrogel-mediated tertiary lymphoid structure formation via activation of the STING pathway for enhanced immunotherapy

XK **, JL Liang, SM Zhang, P Ji, QX Huang… - Materials …, 2023 - pubs.rsc.org
Tertiary lymphoid structures (TLSs) primarily constructed by multiple immune cells can
effectively enhance tumor immune responses, but expediting the formation of TLSs is still an …

Zinc‐Organometallic Framework Vaccine Controlled‐Release Zn2+ Regulates Tumor Extracellular Matrix Degradation Potentiate Efficacy of Immunotherapy

L Ding, M Liang, Y Li, M Zeng, M Liu, W Ma… - Advanced …, 2023 - Wiley Online Library
Tumor extracellular matrix (ECM) not only forms a physical barrier for T cells infiltration, but
also regulates multiple immunosuppressive pathways, which is an important reason for …

[HTML][HTML] Engineering customized nanovaccines for enhanced cancer immunotherapy

J Guo, C Liu, Z Qi, T Qiu, J Zhang, H Yang - Bioactive Materials, 2024 - Elsevier
Nanovaccines have gathered significant attention for their potential to elicit tumor-specific
immunological responses. Despite notable progress in tumor immunotherapy, nanovaccines …