Effect of natural mutations of SARS-CoV-2 on spike structure, conformation, and antigenicity
INTRODUCTION Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
2) have been circulating worldwide since the beginning of the pandemic. Some are termed …
[HTML][HTML] D614G mutation alters SARS-CoV-2 spike conformation and enhances protease cleavage at the S1/S2 junction
The severe acute respiratory coronavirus 2 (SARS-CoV-2) spike (S) protein is the target of
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite …
vaccine design efforts to end the coronavirus disease 2019 (COVID-19) pandemic. Despite …
AlphaFold2 models indicate that protein sequence determines both structure and dynamics
Abstract AlphaFold 2 (AF2) has placed Molecular Biology in a new era where we can
visualize, analyze and interpret the structures and functions of all proteins solely from their …
visualize, analyze and interpret the structures and functions of all proteins solely from their …
Leveraging base-pair mammalian constraint to understand genetic variation and human disease
Thousands of genomic regions have been associated with heritable human diseases, but
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
attempts to elucidate biological mechanisms are impeded by an inability to discern which …
Cryo-EM structures of SARS-CoV-2 Omicron BA. 2 spike
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron BA. 2 sub-
lineage has gained in proportion relative to BA. 1. Because spike (S) protein variations may …
lineage has gained in proportion relative to BA. 1. Because spike (S) protein variations may …
Conformations of KRAS4B affected by its partner binding and G12C mutation: insights from GaMD trajectory-image transformation-based deep learning
J Chen, J Wang, W Yang, L Zhao… - Journal of Chemical …, 2024 - ACS Publications
Binding of partners and mutations highly affects the conformational dynamics of KRAS4B,
which is of significance for deeply understanding its function. Gaussian accelerated …
which is of significance for deeply understanding its function. Gaussian accelerated …
High throughput and quantitative enzymology in the genomic era
Accurate predictions from models based on physical principles are the ultimate metric of our
biophysical understanding. Although there has been stunning progress toward structure …
biophysical understanding. Although there has been stunning progress toward structure …
Computational methods for unlocking the secrets of potassium channels: Structure, mechanism, and drug design
L Wang, Q Zhang, HHY Tong, X Yao… - Wiley Interdisciplinary …, 2024 - Wiley Online Library
Potassium (K+) channels play vital roles in various physiological functions, including
regulating K+ flow in cell membranes, impacting nervous system signal transduction …
regulating K+ flow in cell membranes, impacting nervous system signal transduction …
Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion
Akkermansia muciniphila is a human microbial symbiont residing in the mucosal layer of the
large intestine. Its main carbon source is the highly heterogeneous mucin glycoprotein, and …
large intestine. Its main carbon source is the highly heterogeneous mucin glycoprotein, and …
Investigation of antioxidant and antibacterial effects of citrus fruits peels extracts using different extracting agents: Phytochemical analysis with in silico studies
The peels extracted from various citrus species are major source of phenols, flavonoids and
anti-microbial agents. The purpose of this study was a detailed investigation of the …
anti-microbial agents. The purpose of this study was a detailed investigation of the …