Cystathionine-β-synthase (CBS), the first (and rate-limiting) enzyme in the transsulfuration
pathway, is an important mammalian enzyme in health and disease. Its biochemical …

Significance: Cancer represents a major socioeconomic problem; there is a significant need
for novel therapeutic approaches targeting tumor-specific pathways. Recent Advances: In …

Major Depression disorder (MDD) is a potentially life-threatening mental illness, however,
many patients have a poor response to current treatments. Recent studies have suggested …

Torpor and hibernation are powerful strategies enabling animals to survive periods of low
resource availability. The state of torpor results from an active and drastic reduction of an …

Most mammals adapt thermal physiology around 37° C and large deviations from their
range, as observed in severe hypothermia and hyperthermia, resulting in organ dysfunction …

Abstract Significance: Although oxygen (O2)-sensing cells and tissues have been known for
decades, the identity of the O2-sensing mechanism has remained elusive. Evidence is …

Hibernation is a state of reduced metabolic activity used by some animals to survive in harsh
environmental conditions. The idea of exploiting hibernation for space exploration has been …

Autonomic thermoregulation is a recently acquired function, as it appears for the first time in
mammals and provides the brain with the ability to control energy expenditure. The …

Mammalian hibernators endure severe and prolonged hypothermia that is lethal to non-
hibernators, including humans and mice. The mechanisms responsible for the cold …

For long-duration manned space missions to Mars and beyond, reduction of astronaut
metabolism by torpor, the metabolic state during hibernation of animals, would be a game …