The presence of bacterial persisters is a key factor contributing to chronic infection.
However, no effective treatment methods are currently available. Thus, a platform is …

Introduction Bacterial resistance presents a major challenge to both the ecological
environment and human well-being, with persistence playing a key role. Multiple studies …

Enterococcus, particularly E. faecium and E. faecalis, are responsible for many hospital-
acquired infections. With their intrinsic antibiotic resistance and ability to form biofilms …

Introduction Bacteria must combat phages, and myriad bacterial anti-phage systems have
been discovered that reduce host metabolism, for example, by depleting energetic …

Background Biofilm antibiotic tolerance is partly explained by the behavior of a biofilm as an
independent pharmacokinetic micro-compartment. Hyperbaric oxygen therapy has been …

Bacterial persisters are a multidrug-tolerant subpopulation capable of surviving and
resuscitating after lethal antibiotic treatment, leading to relapsing infections and the …

Rosettes are self-organizing, circular multicellular communities that initiate developmental
processes, like organogenesis and embryogenesis, in complex organisms. Their formation …

ABSTRACT DNA repair machinery has been found to be indispensable for fluoroquinolone
(FQ) persistence of Escherichia coli. Previously, we found that cells harboring two copies of …

Metabolic inhibitors are known to exhibit complex interactions with antibiotics in bacteria,
potentially acting as antagonists by inducing cell dormancy and promoting cell survival …

Resistance, tolerance, and persistence to antibiotics have mainly been studied at the level of
a single microbial isolate. However, in recent years it has become evident that microbial …