Programming mammalian cell behaviors by physical cues

J Huang, M Fussenegger - Trends in Biotechnology, 2024 - cell.com
In recent decades, the field of synthetic biology has witnessed remarkable progress, driving
advances in both research and practical applications. One pivotal area of development …

Application of super-resolution microscopy in mitochondria-dynamic diseases

W Zou, L Yang, H Lu, M Li, D Ji, J Slone… - Advanced Drug Delivery …, 2023 - Elsevier
Limited by spatial and temporal resolution, traditional optical microscopy cannot image the
delicate ultra-structure organelles and sub-organelles. The emergence of super-resolution …

Revealing Mitochondrion–Lysosome Dynamic Interactions and pH Variations in Live Cells with a pH-Sensitive Fluorescent Probe

J Wang, JT Yan, ST Zeng, W Shao, GX Tang… - Analytical …, 2023 - ACS Publications
Mitochondrion–lysosome interactions have garnered significant attention in recent research.
Numerous studies have shown that mitochondrion–lysosome interactions, including …

Repurposing cyanine photoinstability to develop near-infrared light-activatable nanogels for in vivo cargo delivery

R Tapia Hernandez, MC Lee, AK Yadav… - Journal of the American …, 2022 - ACS Publications
The favorable properties of cyanines (eg, near-infrared (NIR) absorbance and emission)
have made this class of dyes popular for a wide variety of biomedical applications. However …

2D MoS2 and BN Nanosheets Damage Mitochondria through Membrane Penetration

K Qiu, W Zou, Z Fang, Y Wang, S Bell, X Zhang… - ACS …, 2023 - ACS Publications
With the progression of nanotechnology, a growing number of nanomaterials have been
created and incorporated into organisms and ecosystems, which raises significant concern …

Constant conversion rate of endolysosomes revealed by a pH-sensitive fluorescent probe

R Chen, L Wang, G Ding, G Han, K Qiu, Y Sun… - ACS …, 2023 - ACS Publications
Endolysosome dynamics plays an important role in autophagosome biogenesis. Hence,
imaging the subcellular dynamics of endolysosomes using high-resolution fluorescent …

Super-resolution fluorescence microscopic imaging in pathogenesis and drug treatment of neurological disease

J Gong, Z **, H Chen, J He, Y Zhang… - Advanced Drug Delivery …, 2023 - Elsevier
Since super-resolution fluorescence microscopic technology breaks the diffraction limit that
has existed for a long time in optical imaging, it can observe the process of synapses formed …

[HTML][HTML] Mitochondrial nucleoid condensates drive peripheral fission through high membrane curvature

Q Chen, LY Liu, Z Tian, Z Fang, KN Wang, X Shao… - Cell Reports, 2023 - cell.com
Mitochondria are dynamic organelles that undergo fusion and fission events, in which the
mitochondrial membrane and DNA (mtDNA) play critical roles. The spatiotemporal …

A general design of pyridinium-based fluorescent probes for enhancing two-photon microscopy

R Chen, K Qiu, DCY Leong, BK Kundu, C Zhang… - Biosensors and …, 2023 - Elsevier
Two-photon absorbing fluorescent probes have emerged as powerful imaging tools for
subcellular-level monitoring of biological substances and processes, offering advantages …

The clinical potential of optogenetic interrogation of pathogenesis

TT Gao, TJ Oh, K Mehta, YEA Huang… - Clinical and …, 2023 - Wiley Online Library
Background Opsin‐based optogenetics has emerged as a powerful biomedical tool using
light to control protein conformation. Such capacity has been initially demonstrated to control …