The uptake of calcium into and extrusion of calcium from the mitochondrial matrix is a
fundamental biological process that has critical effects on cellular metabolism, signaling …

Mitochondria play key roles in activating apoptosis in mammalian cells. Bcl-2 family
members regulate the release of proteins from the space between the mitochondrial inner …

Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

Here we define the molecular nature of the mitochondrial permeability transition pore (PTP),
a key effector of cell death. The PTP is regulated by matrix cyclophilin D (CyPD), which also …

The mitochondrial permeability transition (PT) is a permeability increase of the inner
mitochondrial membrane mediated by a channel, the permeability transition pore (PTP) …

Major progress has been made in defining the basis of the mitochondrial permeability
transition, a Ca2+‐dependent permeability increase of the inner membrane that has puzzled …

Under conditions of mitochondrial calcium overload, especially when accompanied by
oxidative stress, elevated phosphate concentrations and adenine nucleotide depletion, a …

The mitochondrial permeability transition (PT)–an abrupt increase permeability of the inner
membrane to solutes–is a causative event in ischemia–reperfusion injury of the heart, and …

Accumulating evidence reveals that metabolic and cell survival pathways are closely
related, sharing common signaling molecules. Hexokinase catalyzes the phosphorylation of …