ImmunoPET: concept, design, and applications

W Wei, ZT Rosenkrans, J Liu, G Huang, QY Luo… - Chemical …, 2020 - ACS Publications
Immuno-positron emission tomography (immunoPET) is a paradigm-shifting molecular
imaging modality combining the superior targeting specificity of monoclonal antibody (mAb) …

Matching chelators to radiometals for radiopharmaceuticals

EW Price, C Orvig - Chemical Society Reviews, 2014 - pubs.rsc.org
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

[HTML][HTML] Implications of physics, chemistry and biology for dosimetry calculations using theranostic pairs

C Miller, J Rousseau, CF Ramogida, A Celler… - Theranostics, 2022 - ncbi.nlm.nih.gov
Theranostics is an emerging paradigm that combines imaging and therapy in order to
personalize patient treatment. In nuclear medicine, this is achieved by using …

Molecular targeting of epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR)

NEM Kaufman, S Dhingra, SD Jois, MGH Vicente - Molecules, 2021 - mdpi.com
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor
(VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins …

The Beginning and Development of the Theranostic Approach in Nuclear Medicine, as Exemplified by the Radionuclide Pair 86Y and 90Y

F Rösch, H Herzog, SM Qaim - Pharmaceuticals, 2017 - mdpi.com
In the context of radiopharmacy and molecular imaging, the concept of theranostics entails a
therapy-accompanying diagnosis with the aim of a patient-specific treatment. Using the …

Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges

TK Nayak, MW Brechbiel - Bioconjugate chemistry, 2009 - ACS Publications
Radioimmunoimaging and therapy has been an area of interest for several decades. Steady
progress has been made toward clinical translation of radiolabeled monoclonal antibodies …

Metallic radionuclides in the development of diagnostic and therapeutic radiopharmaceuticals

S Bhattacharyya, M Dixit - Dalton transactions, 2011 - pubs.rsc.org
Metallic radionuclides are the mainstay of both diagnostic and therapeutic
radiopharmaceuticals. Therapeutic nuclear medicine is less advanced but has tremendous …

Cancer radioimmunotherapy

RM Sharkey, DM Goldenberg - Immunotherapy, 2011 - Taylor & Francis
Targeting of radionuclides with antibodies, or radioimmunotherapy, has been an active field
of research spanning nearly 50 years, evolving with advancing technologies in molecular …

[HTML][HTML] Image guided biodistribution and pharmacokinetic studies of theranostics

H Ding, F Wu - Theranostics, 2012 - ncbi.nlm.nih.gov
Image guided technique is playing an increasingly important role in the investigation of the
biodistribution and pharmacokinetics of drugs or drug delivery systems in various diseases …

H4octapa: An Acyclic Chelator for 111In Radiopharmaceuticals

EW Price, JF Cawthray, GA Bailey… - Journal of the …, 2012 - ACS Publications
This preliminary investigation of the octadentate acyclic chelator H4octapa (N4O4) with
111In/115In3+ has demonstrated it to be an improvement on the shortcomings of the current …