Molecular and cellular insights into T cell exhaustion
EJ Wherry, M Kurachi - Nature reviews immunology, 2015 - nature.com
In chronic infections and cancer, T cells are exposed to persistent antigen and/or
inflammatory signals. This scenario is often associated with the deterioration of T cell …
inflammatory signals. This scenario is often associated with the deterioration of T cell …
The diverse functions of the PD1 inhibitory pathway
AH Sharpe, KE Pauken - Nature Reviews Immunology, 2018 - nature.com
T cell activation is a highly regulated process involving peptide–MHC engagement of the T
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
cell receptor and positive costimulatory signals. Upon activation, coinhibitory'checkpoints' …
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick… - Nature, 2017 - nature.com
Despite the success of monotherapies based on blockade of programmed cell death 1 (PD-
1) in human melanoma, most patients do not experience durable clinical benefit. Pre …
1) in human melanoma, most patients do not experience durable clinical benefit. Pre …
Functional T cells are capable of supernumerary cell division and longevity
Differentiated somatic mammalian cells putatively exhibit species-specific division limits that
impede cancer but may constrain lifespans,–. To provide immunity, transiently stimulated …
impede cancer but may constrain lifespans,–. To provide immunity, transiently stimulated …
Overcoming T cell exhaustion in infection and cancer
Inhibitors of the Programmed Cell Death 1: Programmed Cell Death 1 ligand 1 (PD-1: PD-
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
L1) pathway, a central regulator of T cell exhaustion, have been recently shown to be …
Proliferation of PD-1+ CD8 T cells in peripheral blood after PD-1–targeted therapy in lung cancer patients
AO Kamphorst, RN Pillai, S Yang… - Proceedings of the …, 2017 - National Acad Sciences
Exhausted T cells in chronic infections and cancer have sustained expression of the
inhibitory receptor programmed cell death 1 (PD-1). Therapies that block the PD-1 pathway …
inhibitory receptor programmed cell death 1 (PD-1). Therapies that block the PD-1 pathway …
Exhausted CD8+ T cells in the tumor immune microenvironment: new pathways to therapy
W Jiang, Y He, W He, G Wu, X Zhou, Q Sheng… - Frontiers in …, 2021 - frontiersin.org
Tumor-specific CD8+ T cells are exposed to persistent antigenic stimulation which induces a
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …
OMIP‐069: forty‐color full spectrum flow cytometry panel for deep immunophenoty** of major cell subsets in human peripheral blood
LM Park, J Lannigan, MC Jaimes - Cytometry Part A, 2020 - Wiley Online Library
PURPOSE AND APPROPRIATE SAMPLE TYPES This 40‐color flow cytometry‐based panel
was developed for in‐depth immunophenoty** of the major cell subsets present in human …
was developed for in‐depth immunophenoty** of the major cell subsets present in human …
Rethinking peripheral T cell tolerance: checkpoints across a T cell's journey
MA ElTanbouly, RJ Noelle - Nature Reviews Immunology, 2021 - nature.com
Following their exit from the thymus, T cells are endowed with potent effector functions but
must spare host tissue from harm. The fate of these cells is dictated by a series of …
must spare host tissue from harm. The fate of these cells is dictated by a series of …
T cell dysfunction in cancer immunity and immunotherapy
A **a, Y Zhang, J Xu, T Yin, XJ Lu - Frontiers in immunology, 2019 - frontiersin.org
In cancer, T cells become dysfunctional owing to persistent antigen exposure. Dysfunctional
T cells are characterized by reduced proliferative capacity, decreased effector function, and …
T cells are characterized by reduced proliferative capacity, decreased effector function, and …