Accurate control of gene expression is essential for normal development and dysregulation
of transcription underpins cancer onset and progression. Similar to cell cycle regulation …

Protein phosphorylation is one of the most widespread post-translational modifications in
biology,. With advances in mass-spectrometry-based phosphoproteomics, 90,000 sites of …

Herein, we discuss more than 50 cyclin-dependent kinase (CDK) inhibitors that have been
approved or have undergone clinical trials and their therapeutic application in multiple …

Transcription progression is governed by multitasking regulators including SPT5, an
evolutionarily conserved factor implicated in virtually all transcriptional steps from enhancer …

Transcription of eukaryotic genes by RNA polymerase II (Pol II) yields RNA precursors
containing introns that must be spliced out and the flanking exons ligated together. Splicing …

CDK7 has emerged as an exciting target in oncology due to its roles in two important
processes that are misregulated in cancer cells: cell cycle and transcription. This report …

RNA surveillance pathways detect and degrade defective transcripts to ensure RNA fidelity.
We found that disrupted nuclear RNA surveillance is oncogenic. Cyclin-dependent kinase …

Transcriptional deregulation has emerged as a hallmark of several cancer types. In
metastatic castration-resistant prostate cancer, a stage in which systemic androgen …

Introduction The emergence of resistance to the highly successful BCL2-directed therapy is
a major unmet need in acute myeloid leukemia (AML), an aggressive malignancy with poor …

In cells, signal transduction heavily relies on the intricate regulation of protein kinases, which
provide the fundamental framework for modulating most signaling pathways. Dysregulation …