Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis

PM Mishra, NC Verma, C Rao, VN Uversky… - Progress in molecular …, 2020 - Elsevier
Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be
distinguished from other proteins in terms of lack of any fixed structure. Such dynamic …

[HTML][HTML] Computational prediction of MoRFs, short disorder-to-order transitioning protein binding regions

A Katuwawala, Z Peng, J Yang, L Kurgan - Computational and Structural …, 2019 - Elsevier
Molecular recognition features (MoRFs) are short protein-binding regions that undergo
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …

Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses

R Giri, T Bhardwaj, M Shegane, BR Gehi… - Cellular and Molecular …, 2021 - Springer
The recently emerged coronavirus designated as SARS-CoV-2 (also known as 2019 novel
coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus …

Hydroxychloroquine inhibits Zika virus NS2B-NS3 protease

A Kumar, B Liang, M Aarthy, SK Singh, N Garg… - ACS …, 2018 - ACS Publications
Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the
context of maternal infection during pregnancy. An important target for drugs combatting Zika …

Role of multiomics data to understand host–pathogen interactions in COVID-19 pathogenesis

S Aggarwal, A Acharjee, A Mukherjee… - Journal of Proteome …, 2021 - ACS Publications
Human infectious diseases are contributed equally by the host immune system's efficiency
and any pathogens' infectivity. Severe acute respiratory syndrome coronavirus 2 (SARS …

Autoimmune neurological conditions associated with Zika virus infection

Y Acosta-Ampudia, DM Monsalve… - Frontiers in molecular …, 2018 - frontiersin.org
Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical
Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans …

The nuclear pore complex: a target for NS3 protease of dengue and Zika viruses

LA De Jesús-González, M Cervantes-Salazar… - Viruses, 2020 - mdpi.com
During flavivirus infection, some viral proteins move to the nucleus and cellular components
are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of …

Deciphering the dark proteome of Chikungunya virus

A Singh, A Kumar, R Yadav, VN Uversky, R Giri - Scientific reports, 2018 - nature.com
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV
infection has been seen in many tropical and subtropical regions of the biosphere. Current …

Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches

R Yadav, C Selvaraj, M Aarthy, P Kumar… - Journal of …, 2021 - Taylor & Francis
Zika virus (ZIKV), belongs to the flavivirus genus and Flaviviridae family that associated with
serious diseased conditions like microcephaly and other neurological disorders (Guillan …

Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-α/β and Exportin CRM-1

LA De Jesús-González, SN Palacios-Rápalo… - Journal of …, 2023 - Am Soc Microbiol
Flaviviruses have a cytoplasmic replicative cycle, and crucial events, such as genome
translation and replication, occur in the endoplasmic reticulum. However, some viral …