Intrinsically disordered proteins of viruses: Involvement in the mechanism of cell regulation and pathogenesis
Intrinsically disordered proteins (IDPs) possess the property of inherent flexibility and can be
distinguished from other proteins in terms of lack of any fixed structure. Such dynamic …
distinguished from other proteins in terms of lack of any fixed structure. Such dynamic …
[HTML][HTML] Computational prediction of MoRFs, short disorder-to-order transitioning protein binding regions
Molecular recognition features (MoRFs) are short protein-binding regions that undergo
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …
disorder-to-order transitions (induced folding) upon binding protein partners. These regions …
Understanding COVID-19 via comparative analysis of dark proteomes of SARS-CoV-2, human SARS and bat SARS-like coronaviruses
The recently emerged coronavirus designated as SARS-CoV-2 (also known as 2019 novel
coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus …
coronavirus (2019-nCoV) or Wuhan coronavirus) is a causative agent of coronavirus …
Hydroxychloroquine inhibits Zika virus NS2B-NS3 protease
Zika virus is a mosquito-transmitted flavivirus that causes devastating fetal outcomes in the
context of maternal infection during pregnancy. An important target for drugs combatting Zika …
context of maternal infection during pregnancy. An important target for drugs combatting Zika …
Role of multiomics data to understand host–pathogen interactions in COVID-19 pathogenesis
Human infectious diseases are contributed equally by the host immune system's efficiency
and any pathogens' infectivity. Severe acute respiratory syndrome coronavirus 2 (SARS …
and any pathogens' infectivity. Severe acute respiratory syndrome coronavirus 2 (SARS …
Autoimmune neurological conditions associated with Zika virus infection
Zika virus (ZIKV) is an emerging flavivirus rapidly spreading throughout the tropical
Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans …
Americas. Aedes mosquitoes is the principal way of transmission of the virus to humans …
The nuclear pore complex: a target for NS3 protease of dengue and Zika viruses
LA De Jesús-González, M Cervantes-Salazar… - Viruses, 2020 - mdpi.com
During flavivirus infection, some viral proteins move to the nucleus and cellular components
are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of …
are relocated from the nucleus to the cytoplasm. Thus, the integrity of the main regulator of …
Deciphering the dark proteome of Chikungunya virus
Chikungunya virus (CHIKV) is a mosquito-borne alphavirus. The outbreak of CHIKV
infection has been seen in many tropical and subtropical regions of the biosphere. Current …
infection has been seen in many tropical and subtropical regions of the biosphere. Current …
Investigating into the molecular interactions of flavonoids targeting NS2B-NS3 protease from ZIKA virus through in-silico approaches
Zika virus (ZIKV), belongs to the flavivirus genus and Flaviviridae family that associated with
serious diseased conditions like microcephaly and other neurological disorders (Guillan …
serious diseased conditions like microcephaly and other neurological disorders (Guillan …
Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-α/β and Exportin CRM-1
LA De Jesús-González, SN Palacios-Rápalo… - Journal of …, 2023 - Am Soc Microbiol
Flaviviruses have a cytoplasmic replicative cycle, and crucial events, such as genome
translation and replication, occur in the endoplasmic reticulum. However, some viral …
translation and replication, occur in the endoplasmic reticulum. However, some viral …