OBJECTIVE:: To summarize recent knowledge on the small molecular weight protein
cystatin C (cys-C) and its use as a marker of the glomerular filtration rate (GFR). METHODS …

Background: Glomerular filtration rate (GFR) is routinely assessed by measuring the
concentrations of endogenous serum markers such as blood urea nitrogen and serum …

Since 1985, cystatin C has been suggested to be a marker of the renal function. Cystatin C is
a proteinase inhibitor with a low molecular weight (M r= 13359). It is produced at a constant …

Low molecular-mass plasma proteins play a key role in health and disease. Cystatin C is an
endogenous cysteine proteinase inhibitor belonging to the type 2 cystatin superfamily. The …

Publisher Summary This chapter focuses on the most well characterized inhibitors—cystatin
C—and provide some information on its structure, biochemical properties, its role in normal …

Background: Serum creatinine is the most commonly used marker for estimation of
glomerular filtration rate (GFR). To compensate for its drawbacks as a GFR marker, several …

Cystatin C is a more sensitive marker than creatinine for the estimation of GFR in type 2
diabetic patients. Background Glomerular filtration rate (GFR) is the best overall index of …

Serum cystatin C is a novel marker of renal function claimed to be superior to plasma
creatinine. We assessed both parameters in young normotensive subjects (n= 12; 6 men; …

Clinical biochemists have long known the analytical and clinical limitations of creatinine and
creatinine clearance measurement in the assessment of glomerular filtration rate (GFR). This …

Research on early renal function decline in diabetes is hampered by lack of simple tools for
detecting trends (particularly systematic decreases) in renal function over time when GFR is …