A review on the modern synthetic approach of benzimidazole candidate

M Faheem, A Rathaur, A Pandey… - …, 2020 - Wiley Online Library
Benzimidazole structure contains imidazole ring fused with phenyl ring at 4‐and 5‐position.
The mono and disubstituted derivatives of benzimidazole are very interesting heterocyclic …

Benzimidazole scaffolds as promising antiproliferative agents: A review

S Tahlan, S Kumar, S Kakkar, B Narasimhan - BMC chemistry, 2019 - Springer
Cancer is one of the most serious medical problem and second leading cause of death in
the world, characterized by a deregulation of the cell cycle which mainly results in a …

Efficient synthesis of 1, 2-disubstituted benzimidazoles catalyzed by phosphoric acid as a homogeneous catalyst under mild conditions and investigating their anti …

AM Bistgani, A Dehghani, L Moradi - RSC advances, 2023 - pubs.rsc.org
A green practical method for the efficient synthesis of 1-benzyl-2-phenyl-benzimidazole and
its derivatives using phosphoric acid as an eco-friendly homogeneous catalyst from the …

Recent advances in the synthesis of perimidines and their applications

N Sahiba, S Agarwal - Topics in Current Chemistry, 2020 - Springer
Perimidines are versatile scaffolds and a fascinating class of N-heterocycles that have
evolved significantly in recent years due to their immense applications in life sciences …

Synthesis and anti-cancer applications of benzimidazole derivatives-recent studies

YK Tyagi, G Jali, R Singh - Anti-Cancer Agents in Medicinal …, 2022 - benthamdirect.com
Background: Cancer is a life-threatening disease. Anti-cancer drugs are the focus of
research. The heterocyclic molecules like benzimidazole occupy a central position in …

Novel Synthesis of Functionalized Bis(Benzo‐Heterocyclic Amine) Derivatives via Copper‐Catalyzed One‐Pot Multicomponent Reactions

M Nematpour - ChemistrySelect, 2024 - Wiley Online Library
A copper‐catalyzed one‐pot synthesis of substituted bis (benzoxazole) amine, N‐
benzoxazole (benzoimidazole) amine, and N‐benzoxazole (benzothiazole) amine is …

Synthesis of benzimidazole by mortar–pestle grinding method

P Zhang, C Liu, L Yu, H Hou, W Sun… - Green Chemistry Letters …, 2021 - Taylor & Francis
An environmentally friendly and efficient protocol for the synthesis of benzimidazoles by
mortar–pestle grinding technique in the presence of acetic acid as a catalyst is reported …

Contemporary progress in the synthetic strategies of imidazole and its biological activities

J Soni, A Sethiya, N Sahiba, DK Agarwal… - Current Organic …, 2019 - ingentaconnect.com
Heterocyclic compounds are pervasive in many areas of life and one of the heterocycles,
imidazole is a unique heterocyclic five-membered aromatic compound having two sp2 …

The fundamental nature and importance of electrostatic potential in hydrogen bond formation: a case study of heterocycles frequently observed in drugs

M Haritha, CH Suresh - New Journal of Chemistry, 2023 - pubs.rsc.org
Molecular electrostatic potential (MESP) analysis is employed to predict the hydrogen bond
(HB) interaction strength (Eint) of frequently encountered chemical motifs (CO–HC, CN–HN …

Triazolo‐linked benzimidazoles as tubulin polymerization inhibitors and DNA intercalators: Design, synthesis, cytotoxicity, and docking studies

K Laxmikeshav, M Sayali, G Devabattula… - Archiv der …, 2023 - Wiley Online Library
A simple “click” protocol was employed in the quest of synthesizing 1, 2, 3‐triazole‐linked
benzimidazoles as promising anticancer agents on various human cancer cell lines such as …