Sedentary behaviors (SB) are characterized by low energy expenditure while in a sitting or
reclining posture. Evidence relevant to understanding the physiology of SB can be derived …

Mitochondria play important roles in maintaining cellular homeostasis and skeletal muscle
health, and damage to mitochondria can lead to a series of pathophysiological changes …

Mechanisms underlying mechanical overload-induced skeletal muscle hypertrophy have
been extensively researched since the landmark report by Morpurgo (1897) of “work …

Human skeletal muscle demonstrates remarkable plasticity, adapting to numerous external
stimuli including the habitual level of contractile loading. Accordingly, muscle function and …

Declines in physical performance and cognition are commonly observed in older adults. The
geroscience paradigm posits that a set of processes and pathways shared among age …

Skeletal muscle, which accounts for approximately 40% of total body weight, is one of the
most dynamic and plastic tissues in the human body and plays a vital role in movement …

Myostatin (MSTN), a member of the transforming growth factor-β superfamily, can negatively
regulate the growth and development of skeletal muscle by autocrine or paracrine signaling …

A molecular clock network is crucial for daily physiology and maintaining organismal health.
We examined the interactions and importance of intratissue clock networks in muscle tissue …

The progressive loss of skeletal muscle mass and concomitant reduction in contractile
strength plays a central role in frailty syndrome. Age-related neuronal impairments are …

In the last decade, clear evidence has emerged that the cellular components of skeletal
muscle are important sites for the release of proteins and peptides called “myokines” …