Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting
either the central nervous system or a variety of peripheral tissues. Structural and dynamic …

In contrast to synthetic materials, evolutionary developments in biology have resulted in
materials with remarkable structural properties, made out of relatively weak constituents …

Exploring the landscape of large scale conformational changes such as protein folding at
atomistic detail poses a considerable computational challenge. Coarse-grained …

Nanostructured scaffolds recently showed great promise in tissue engineering:
nanomaterials can be tailored at the molecular level and scaffold morphology may more …

The aggregation of soluble proteins into fibrillar species is a complex process that spans
many lengths and time scales, and that involves the formation of numerous on-pathway and …

Computational tools are increasingly being applied to solve the protein aggregation
problem, providing insight into amyloid structures and aggregation mechanisms. The …

Highlights•Low complexity (LC) sequences are prominent in eukaryotic proteomes.•LC
sequences are composed of a parsimonious subset of the naturally occurring amino …

Protein aggregation is a topic of immense interest to the scientific community due to its role
in several neurodegenerative diseases/disorders and industrial importance. Several in silico …

Aberrant protein folding known as protein misfolding is counted as one of the striking factors
of neurodegenerative diseases. The extensive range of pathologies caused by protein …

Interest in amyloidogenesis has exploded in recent years, as scientists recognize the role of
amyloid protein aggregates in degenerative diseases such as Alzheimer's and Parkinson's …