Cyclic dipeptides: The biological and structural landscape with special focus on the anti-cancer proline-based scaffold
Cyclic dipeptides, also know as diketopiperazines (DKP), the simplest cyclic forms of
peptides widespread in nature, are unsurpassed in their structural and bio-functional …
peptides widespread in nature, are unsurpassed in their structural and bio-functional …
Not so innocent: Impact of fluorophore chemistry on the in vivo properties of bioconjugates
The combination of targeting ligands and fluorescent dyes is a powerful strategy to observe
cell types and tissues of interest. Conjugates of peptides, proteins, and, in particular …
cell types and tissues of interest. Conjugates of peptides, proteins, and, in particular …
Modular synthesis of clickable peptides via late-stage maleimidation on C (7)-H tryptophan
P Wang, J Liu, X Zhu, Kenry, Z Yan, J Yan… - Nature …, 2023 - nature.com
Cyclic peptides have attracted tremendous attention in the pharmaceutical industry owing to
their excellent cell penetrability, stability, thermostability, and drug-like properties. However …
their excellent cell penetrability, stability, thermostability, and drug-like properties. However …
Rational Design of Phe‐BODIPY Amino Acids as Fluorogenic Building Blocks for Peptide‐Based Detection of Urinary Tract Candida Infections
Fungal infections caused by Candida species are among the most prevalent in hospitalized
patients. However, current methods for the detection of Candida fungal cells in clinical …
patients. However, current methods for the detection of Candida fungal cells in clinical …
Late-stage peptide labeling with near-infrared fluorogenic nitrobenzodiazoles by manganese-catalyzed C–H activation
Late-stage diversification of structurally complex amino acids and peptides provides
tremendous potential for drug discovery and molecular imaging. Specifically, labeling …
tremendous potential for drug discovery and molecular imaging. Specifically, labeling …
Synthesis of Fluorescent Cyclic Peptides via Gold (I)-Catalyzed Macrocyclization
Rapid and efficient cyclization methods that form structurally novel peptidic macrocycles are
of high importance for medicinal chemistry. Herein, we report the first gold (I)-catalyzed …
of high importance for medicinal chemistry. Herein, we report the first gold (I)-catalyzed …
Synthesis of macrocyclic thiolactone peptides via photochemical intramolecular radical acyl thiol–ene ligation
A Benny, EM Scanlan - Chemical Communications, 2024 - pubs.rsc.org
A photochemical acyl thiol–ene reaction can be used to rapidly cyclise fully unprotected
peptides bearing both a thioacid and alkene to form peptide thiolactones. This strategy …
peptides bearing both a thioacid and alkene to form peptide thiolactones. This strategy …
A photoinduced electron transfer-based hypochlorite-specific fluorescent probe for selective imaging of proinflammatory M1 in a rheumatoid arthritis model
The differentiation of the distinct phenotypes of macrophages is essential for monitoring the
stage of inflammatory diseases for accurate diagnosis and treatment. Recent studies …
stage of inflammatory diseases for accurate diagnosis and treatment. Recent studies …
Solid‐Phase Peptide Macrocyclization and Multifunctionalization via Dipyrrin Construction
We introduce a new and highly efficient synthetic protocol towards multifunctional
fluorescent cyclopeptides by solid‐phase peptide macrocyclization via dipyrrin construction …
fluorescent cyclopeptides by solid‐phase peptide macrocyclization via dipyrrin construction …
Solution‐Phase Late‐Stage Chemoselective Photocatalytic Removal of Sulfonyl and Phenacyl Groups in Peptides
Herein, BPC catalyzed visible‐light‐triggered target‐specific late‐stage solution phase
desulfonylation from tryptophan in oligopeptides is portrayed by overcoming the isolation …
desulfonylation from tryptophan in oligopeptides is portrayed by overcoming the isolation …