Review of applications of high-throughput sequencing in personalized medicine: barriers and facilitators of future progress in research and clinical application

G Lightbody, V Haberland, F Browne… - Briefings in …, 2019 - academic.oup.com
There has been an exponential growth in the performance and output of sequencing
technologies (omics data) with full genome sequencing now producing gigabases of reads …

Reconfiguring the bioinformatics computational spectrum: Challenges and opportunities of fpga-based bioinformatics acceleration platforms

G Chrysos, E Sotiriades, C Rousopoulos… - IEEE Design & …, 2013 - ieeexplore.ieee.org
This paper conducts a detailed survey on the use of FPGA-based reconfigurable computing
platforms for a wide range of sequence and structural bioinformatics applications, with …

AIM: accelerating computational genomics through scalable and noninvasive accelerator-interposed memory

J Cong, Z Fang, M Gill, F Javadi… - Proceedings of the …, 2017 - dl.acm.org
Computational genomics plays an important role in health care, but is computationally
challenging as most genomics applications use large data sets and are both computation …

FPGA-based hardware accelerator for an embedded factor graph with configurable optimization

I Sugiarto, C Axenie, J Conradt - Journal of Circuits, Systems and …, 2019 - World Scientific
A factor graph (FG) can be considered as a unified model combining a Bayesian network
(BN) and a Markov random field (MRF). The inference mechanism of a FG can be used to …

WImpiBLAST: Web interface for mpiBLAST to help biologists perform large-scale annotation using high performance computing

P Sharma, SS Mantri - PLoS One, 2014 - journals.plos.org
The function of a newly sequenced gene can be discovered by determining its sequence
homology with known proteins. BLAST is the most extensively used sequence analysis …

ACA-SDS: Adaptive crypto acceleration for secure data storage in big data

C **ao, P Li, L Zhang, W Liu, N Bergmann - IEEE Access, 2018 - ieeexplore.ieee.org
In the era of big data, the demand for secure data storage is rapidly increasing. To
accelerate the complex encryption computation, both specific instructions and hardware …

GPU technology as a platform for accelerating local complexity analysis of protein sequences

A Papadopoulos, I Kirmitzoglou… - 2013 35th Annual …, 2013 - ieeexplore.ieee.org
The use of GPGPU programming paradigm (running CUDA-enabled algorithms on GPU
cards) in Bioinformatics showed promising results [1]. As such a similar approach can be …

Custom hardware versus cloud computing in big data

G Lightbody, F Browne, V Haberland - … Information: From the Big Bang to …, 2017 - Springer
The computational and data handling challenges in big data are immense yet a market is
steadily growing traditionally supported by technologies such as Hadoop for management …

Modular design of a factor-graph-based inference engine on a System-On-Chip (SoC)

I Sugiarto, J Conradt - Microprocessors and Microsystems, 2018 - Elsevier
Factor graphs are probabilistic graphical frameworks for modeling complex and dynamic
systems. They can be used in a broad range of application domains, from machine learning …