Oxidative stress (OS) is a condition that occurs as a result of an imbalance between the
production of reactive oxygen species (ROS) and the body's ability to detoxify and neutralize …

Elwood Jensen and Jack Gorski had spent 10 yr providing experimental evidence to support
the concept of an intracellular “receptor” protein for steroid hormones. Their combined work …

BACKGROUND Chemotherapy treatment in premenopausal women is associated with an
increased risk of premature ovarian failure (POF) but the exact mechanism through which …

Ovulation is a physiologic process defined by the rupture and release of the dominant follicle
from the ovary into the fallopian tube where it has the potential to become fertilized. The …

The corpus luteum (CL) is one of the few endocrine glands that forms from the remains of
another organ and whose function and survival are limited in scope and time. The CL is the …

The enzymes that convert arachidonic acid to prostaglandin H2 are named cyclooxygenase-
1 (COX-1) and COX-2. The properties of COX-1 are different from those of COX-2. It was …

The oestrous cycle in cattle lasts for 18–24 days. It consists of a luteal phase (14–18 days)
and a follicular phase (4–6 days). During the cycle there are generally two (dairy cows) or …

Ovulation is a precisely timed process by which a mature oocyte is released from an ovarian
follicle. This process is initiated by the pituitary surge of luteinizing hormone (LH), is …

LH acts on periovulatory granulosa cells by activating the PKA pathway as well as other cell
signaling cascades to increase the transcription of specific genes necessary for ovulation …

Development-related paracrine cues that sensitize follicles to follicle stimulating hormone
(FSH) and luteinizing hormone (LH) are crucial to the emergence of a single dominant …