Designing nanozymes for in vivo applications

R Zhang, B Jiang, K Fan, L Gao, X Yan - Nature Reviews …, 2024 - nature.com
Biocatalytic drugs, including natural and artificial enzymes that can accelerate biochemical
reactions, are promising tools to address redox imbalances, metabolic disorders and …

Nanozymes: versatile platforms for cancer diagnosis and therapy

X Zhang, X Chen, Y Zhao - Nano-Micro Letters, 2022 - Springer
Natural enzymes usually suffer from high production cost, ease of denaturation and
inactivation, and low yield, making them difficult to be broadly applicable. As an emerging …

A Molybdenum Disulfide Nanozyme with Charge‐Enhanced Activity for Ultrasound‐Mediated Cascade‐Catalytic Tumor Ferroptosis

L Wang, X Zhang, Z You, Z Yang, M Guo… - Angewandte Chemie …, 2023 - Wiley Online Library
The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor
microenvironment (TME) are major obstacles for nanozyme‐mediated catalytic tumor …

Recent advances in multi-configurable nanomaterials for improved chemodynamic therapy

J Lu, Y Yang, Q Xu, Y Lin, S Feng, Y Mao… - Coordination Chemistry …, 2023 - Elsevier
Cancer is one of the most severe culprits that endanger human lives. Numerous novel
nanomaterials and techniques emerge to achieve the enhanced therapeutic efficiency for …

Chemically engineering cells for precision medicine

Y Wang, Z Li, F Mo, TJ Chen-Mayfield, A Saini… - Chemical Society …, 2023 - pubs.rsc.org
Cell-based therapy holds great potential to address unmet medical needs and revolutionize
the healthcare industry, as demonstrated by several therapeutics such as CAR-T cell …

[HTML][HTML] Harnessing a biopolymer hydrogel reinforced by copper/tannic acid nanosheets for treating bacteria-infected diabetic wounds

S You, Y **ang, X Qi, R Mao, E Cai, Y Lan, H Lu… - Materials Today …, 2022 - Elsevier
Current diabetic wound treatments remain difficult in clinical due to bacterial infection and
excessive reactive oxygen species (ROS). An ideal wound dressing should have prominent …

Bioactive bacteria/MOF hybrids can achieve targeted synergistic chemotherapy and chemodynamic therapy against breast tumors

J Li, J Dai, L Zhao, S Lin, Q Wen, Q Wen… - Advanced Functional …, 2023 - Wiley Online Library
The hypoxic tumor microenvironment (TME) significantly affects cancer treatment.
Conventional chemotherapeutic agents cannot effectively target hypoxic tumor tissue, which …

The applications of nanozymes in cancer therapy: based on regulating pyroptosis, ferroptosis and autophagy of tumor cells

Y Zhang, W Yu, M Chen, B Zhang, L Zhang, P Li - Nanoscale, 2023 - pubs.rsc.org
Nanozymes are nanomaterials with catalytic properties similar to those of natural enzymes,
and they have recently been collectively identified as a class of innovative artificial enzymes …

Injectable hydrogels encapsulating dual-functional Au@ Pt core–shell nanoparticles regulate infarcted microenvironments and enhance the therapeutic efficacy of …

W Liu, N Zhao, Q Yin, X Zhao, K Guo, Y **an, S Li… - ACS …, 2023 - ACS Publications
Injectable functional biomaterials have made significant progress in cardiac regenerative. In
addition, how to adjust the abominable infarction microenvironment and introduce …

Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

D Li, D Dai, G **ong, S Lan, C Zhang - Small, 2023 - Wiley Online Library
Most nanozymes in development for medical applications only exhibit single‐enzyme‐like
activity, and are thus limited by insufficient catalytic activity and dysfunctionality in complex …