Sickle cell disease (SCD) is common throughout much of sub-Saharan Africa, affecting up to
3% of births in some parts of the continent. Nevertheless, it remains a low priority for many …

Executive summary All over the world, people with sickle cell disease (an inherited
condition) have premature deaths and preventable severe chronic complications, which …

Background Many children with sickle cell disease living in sub-Saharan Africa die before
reaching age 5 years. We estimate the child mortality associated with sickle cell anaemia …

Sickle cell disease (SCD) is a monogenetic disorder due to a single base-pair point mutation
in the β-globin gene resulting in the substitution of the amino acid valine for glutamic acid in …

Global environmental change and recent worldwide infectious-disease outbreaks make the
ecological perspective of medical anthropology more important a field of study than ever. In …

Background Child mortality from sickle cell disease in sub-Saharan Africa is presumed to be
high but is not well quantified. This uncertainty contributes to the neglect of sickle cell …

Sickle cell disease has been largely an invisible global health issue, especially in regions of
high incidence mainly due to lack of awareness among both the local health policy makers …

Sickle cell disease (SCD) results in chronic hemolytic anemia, recurrent vascular occlusion,
insidious vital organ deterioration, early mortality, and diminished quality of life. Life …

Summary Sickle Cell Disease (SCD) is an increasing global health problem and presents
significant challenges to European health care systems. Newborn screening (NBS) for SCD …

Iron overload and iron toxicity, whether because of increased absorption or iron loading from
repeated transfusions, can be major causes of morbidity and mortality in a number of chronic …