In addition to biochemical signals and genetic considerations, mechanical forces are rapidly
emerging as a master regulator of human physiology. However, the molecular mechanisms …

Filamin A (FLNa) is an actin-binding protein, which participates in the formation of the
cytoskeleton, anchors a variety of proteins in the cytoskeleton and regulates cell adhesion …

Talin, a force-bearing cytoplasmic adapter essential for integrin-mediated cell adhesion,
links the actin cytoskeleton to integrin-based cell–extracellular matrix adhesions at the …

Force sensing at cadherin-mediated adhesions is critical for their proper function. α-Catenin,
which links cadherins to actomyosin, has a crucial role in this mechanosensing process. It …

The force-dependent interaction between talin and vinculin plays a crucial role in the
initiation and growth of focal adhesions. Here we use magnetic tweezers to characterise the …

Mechanical tension is an ever-present physiological stimulus essential for the development
and homeostasis of locomotory, cardiovascular, respiratory, and urogenital systems [1, 2] …

Insight into how molecular machines perform their biological functions depends on
knowledge of the spatial organization of the components, their connectivity, geometry, and …

The mechanical stability of force-bearing proteins is crucial for their functions. However, slow
transition rates of complex protein domains have made it challenging to investigate their …

Filamin C (FLNC) is one of three filamin proteins (Filamin A (FLNA), Filamin B (FLNB), and
FLNC) that cross-link actin filaments and interact with numerous binding partners. FLNC …

Filamin C (FLNC), a large dimeric actin-binding protein in muscle cells, plays a critical role in
transmitting force in the cytoskeleton and that between membrane receptors and the …