Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management

RJ Ellis, MJ Marquine, M Kaul, JA Fields… - Nature Reviews …, 2023 - nature.com
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …

Cognitive impairment in people living with HIV: mechanisms, controversies, and future perspectives

CD Moschopoulos, K Alford, A Antoniadou… - Trends in Molecular …, 2024 - cell.com
Despite the dramatic decrease in HIV-associated neurocognitive impairment (NCI) in the
combined antiretroviral treatment (cART) era, subtler neuropsychological complications …

HIV silencing and cell survival signatures in infected T cell reservoirs

IC Clark, P Mudvari, S Thaploo, S Smith, M Abu-Laban… - Nature, 2023 - nature.com
Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …

Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ART

C Dufour, MJ Ruiz, A Pagliuzza, C Richard, A Shahid… - Cell reports, 2023 - cell.com
HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of
different anatomical compartments to the viral reservoir in humans remains unknown. We …

HIV-1 RNA in extracellular vesicles is associated with neurocognitive outcomes

C DeMarino, J Denniss, M Cowen, G Norato… - Nature …, 2024 - nature.com
Human immunodeficiency virus type-1 (HIV-1) is responsible for significant mortality and
morbidity worldwide. Despite complete control of viral replication with antiretrovirals, cells …

Intact proviral DNA analysis of the brain viral reservoir and relationship to neuroinflammation in people with HIV on suppressive antiretroviral therapy

D Gabuzda, J Yin, V Misra, S Chettimada, BB Gelman - Viruses, 2023 - mdpi.com
HIV establishes a persistent viral reservoir in the brain despite viral suppression in blood to
undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally …

HIV tissue reservoirs: Current advances in research

K Li, B Liu, R Ma, Q Zhang - AIDS patient care and STDs, 2023 - liebertpub.com
Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …

HIV transcription persists in the brain of virally suppressed people with HIV

J Jamal Eddine, TA Angelovich, J Zhou… - PLoS …, 2024 - journals.plos.org
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated
neurocognitive disorders. Whether HIV transcription persists in the brain despite viral …

Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

W Sun, Y Rassadkina, C Gao, SI Collens, X Lian… - Elife, 2023 - elifesciences.org
HIV-1 reservoir cells that circulate in peripheral blood during suppressive antiretroviral
therapy (ART) have been well characterized, but little is known about the dissemination of …

Shock and kill within the CNS: A promising HIV eradication approach?

MM Nühn, SBH Gumbs, NVEJ Buchholtz… - Journal of Leukocyte …, 2022 - academic.oup.com
The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …