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Mechanisms underlying HIV-associated cognitive impairment and emerging therapies for its management
People living with HIV are affected by the chronic consequences of neurocognitive
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …
impairment (NCI) despite antiretroviral therapies that suppress viral replication, improve …
Cognitive impairment in people living with HIV: mechanisms, controversies, and future perspectives
Despite the dramatic decrease in HIV-associated neurocognitive impairment (NCI) in the
combined antiretroviral treatment (cART) era, subtler neuropsychological complications …
combined antiretroviral treatment (cART) era, subtler neuropsychological complications …
HIV silencing and cell survival signatures in infected T cell reservoirs
Rare CD4 T cells that contain HIV under antiretroviral therapy represent an important barrier
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …
to HIV cure,–, but the infeasibility of isolating and characterizing these cells in their natural …
Near full-length HIV sequencing in multiple tissues collected postmortem reveals shared clonal expansions across distinct reservoirs during ART
C Dufour, MJ Ruiz, A Pagliuzza, C Richard, A Shahid… - Cell reports, 2023 - cell.com
HIV persists in tissues during antiretroviral therapy (ART), but the relative contribution of
different anatomical compartments to the viral reservoir in humans remains unknown. We …
different anatomical compartments to the viral reservoir in humans remains unknown. We …
HIV-1 RNA in extracellular vesicles is associated with neurocognitive outcomes
Human immunodeficiency virus type-1 (HIV-1) is responsible for significant mortality and
morbidity worldwide. Despite complete control of viral replication with antiretrovirals, cells …
morbidity worldwide. Despite complete control of viral replication with antiretrovirals, cells …
Intact proviral DNA analysis of the brain viral reservoir and relationship to neuroinflammation in people with HIV on suppressive antiretroviral therapy
HIV establishes a persistent viral reservoir in the brain despite viral suppression in blood to
undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally …
undetectable levels on antiretroviral therapy (ART). The brain viral reservoir in virally …
HIV tissue reservoirs: Current advances in research
K Li, B Liu, R Ma, Q Zhang - AIDS patient care and STDs, 2023 - liebertpub.com
Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency
virus (HIV), has become a heavy burden of disease and an important public health problem …
virus (HIV), has become a heavy burden of disease and an important public health problem …
HIV transcription persists in the brain of virally suppressed people with HIV
J Jamal Eddine, TA Angelovich, J Zhou… - PLoS …, 2024 - journals.plos.org
HIV persistence in the brain is a barrier to cure, and potentially contributes to HIV-associated
neurocognitive disorders. Whether HIV transcription persists in the brain despite viral …
neurocognitive disorders. Whether HIV transcription persists in the brain despite viral …
Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy
HIV-1 reservoir cells that circulate in peripheral blood during suppressive antiretroviral
therapy (ART) have been well characterized, but little is known about the dissemination of …
therapy (ART) have been well characterized, but little is known about the dissemination of …
Shock and kill within the CNS: A promising HIV eradication approach?
MM Nühn, SBH Gumbs, NVEJ Buchholtz… - Journal of Leukocyte …, 2022 - academic.oup.com
The most studied HIV eradication approach is the “shock and kill” strategy, which aims to
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …
reactivate the latent reservoir by latency reversing agents (LRAs) and allowing elimination of …