Biomolecular phase separation: from molecular driving forces to macroscopic properties

GL Dignon, RB Best, J Mittal - Annual review of physical …, 2020 - annualreviews.org
Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …

Temperature, hydrostatic pressure, and osmolyte effects on liquid–liquid phase separation in protein condensates: physical chemistry and biological implications

H Cinar, Z Fetahaj, S Cinar, RM Vernon… - … A European Journal, 2019 - Wiley Online Library
Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …

Temperature-controlled liquid–liquid phase separation of disordered proteins

GL Dignon, W Zheng, YC Kim, J Mittal - ACS central science, 2019 - ACS Publications
The liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is a
commonly observed phenomenon within the cell, and such condensates are also highly …

Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions

Y Lin, J McCarty, JN Rauch, KT Delaney, KS Kosik… - Elife, 2019 - elifesciences.org
The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose
pathological aggregation is implicated in neurodegenerative disorders, is not well …

Influence of ionic strength on hydrophobic interactions in water: dependence on solute size and shape

M Bogunia, M Makowski - The Journal of Physical Chemistry B, 2020 - ACS Publications
Hydrophobicity is a phenomenon of great importance in biology, chemistry, and
biochemistry. It is defined as the interaction between nonpolar molecules or groups in water …

Coarse-grained residue-based models of disordered protein condensates: utility and limitations of simple charge pattern parameters

S Das, AN Amin, YH Lin, HS Chan - Physical Chemistry Chemical …, 2018 - pubs.rsc.org
Biomolecular condensates undergirded by phase separations of proteins and nucleic acids
serve crucial biological functions. To gain physical insights into their genetic basis, we study …

Temperature and volumetric effects on structural and dielectric properties of hybrid perovskites

A Nowok, S Sobczak, K Roszak, AZ Szeremeta… - Nature …, 2024 - nature.com
Three-dimensional organic-inorganic perovskites are rapidly evolving materials with diverse
applications. This study focuses on their two representatives-acetamidinium manganese (II) …

Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins

YH Lin, J Song, JD Forman-Kay, HS Chan - Journal of Molecular Liquids, 2017 - Elsevier
Intrinsically disordered proteins (IDPs) are typically low in nonpolar/hydrophobic but
relatively high in polar, charged, and aromatic amino acid compositions. Some IDPs …

Pressure-sensitive and osmolyte-modulated liquid–liquid phase separation of eye-lens γ-crystallins

S Cinar, H Cinar, HS Chan… - Journal of the American …, 2019 - ACS Publications
Biomolecular condensates can be functional (eg, as membrane-less organelles) or
dysfunctional (eg, as precursors to pathological protein aggregates). A major physical …

Biomolecular condensates under extreme martian salt conditions

Z Fetahaj, L Ostermeier, H Cinar, R Oliva… - Journal of the …, 2021 - ACS Publications
Biomolecular condensates formed by liquid–liquid phase separation (LLPS) are considered
one of the early compartmentalization strategies of cells, which still prevail today forming …