Biomolecular phase separation: from molecular driving forces to macroscopic properties
Biological phase separation is known to be important for cellular organization, which has
recently been extended to a new class of biomolecules that form liquid-like droplets …
recently been extended to a new class of biomolecules that form liquid-like droplets …
Temperature, hydrostatic pressure, and osmolyte effects on liquid–liquid phase separation in protein condensates: physical chemistry and biological implications
H Cinar, Z Fetahaj, S Cinar, RM Vernon… - … A European Journal, 2019 - Wiley Online Library
Liquid–liquid phase separation (LLPS) of proteins and other biomolecules play a critical role
in the organization of extracellular materials and membrane‐less compartmentalization of …
in the organization of extracellular materials and membrane‐less compartmentalization of …
Temperature-controlled liquid–liquid phase separation of disordered proteins
The liquid–liquid phase separation (LLPS) of intrinsically disordered proteins (IDPs) is a
commonly observed phenomenon within the cell, and such condensates are also highly …
commonly observed phenomenon within the cell, and such condensates are also highly …
Narrow equilibrium window for complex coacervation of tau and RNA under cellular conditions
The mechanism that leads to liquid-liquid phase separation (LLPS) of the tau protein, whose
pathological aggregation is implicated in neurodegenerative disorders, is not well …
pathological aggregation is implicated in neurodegenerative disorders, is not well …
Influence of ionic strength on hydrophobic interactions in water: dependence on solute size and shape
M Bogunia, M Makowski - The Journal of Physical Chemistry B, 2020 - ACS Publications
Hydrophobicity is a phenomenon of great importance in biology, chemistry, and
biochemistry. It is defined as the interaction between nonpolar molecules or groups in water …
biochemistry. It is defined as the interaction between nonpolar molecules or groups in water …
Coarse-grained residue-based models of disordered protein condensates: utility and limitations of simple charge pattern parameters
Biomolecular condensates undergirded by phase separations of proteins and nucleic acids
serve crucial biological functions. To gain physical insights into their genetic basis, we study …
serve crucial biological functions. To gain physical insights into their genetic basis, we study …
Temperature and volumetric effects on structural and dielectric properties of hybrid perovskites
Three-dimensional organic-inorganic perovskites are rapidly evolving materials with diverse
applications. This study focuses on their two representatives-acetamidinium manganese (II) …
applications. This study focuses on their two representatives-acetamidinium manganese (II) …
Random-phase-approximation theory for sequence-dependent, biologically functional liquid-liquid phase separation of intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) are typically low in nonpolar/hydrophobic but
relatively high in polar, charged, and aromatic amino acid compositions. Some IDPs …
relatively high in polar, charged, and aromatic amino acid compositions. Some IDPs …
Pressure-sensitive and osmolyte-modulated liquid–liquid phase separation of eye-lens γ-crystallins
S Cinar, H Cinar, HS Chan… - Journal of the American …, 2019 - ACS Publications
Biomolecular condensates can be functional (eg, as membrane-less organelles) or
dysfunctional (eg, as precursors to pathological protein aggregates). A major physical …
dysfunctional (eg, as precursors to pathological protein aggregates). A major physical …
Biomolecular condensates under extreme martian salt conditions
Z Fetahaj, L Ostermeier, H Cinar, R Oliva… - Journal of the …, 2021 - ACS Publications
Biomolecular condensates formed by liquid–liquid phase separation (LLPS) are considered
one of the early compartmentalization strategies of cells, which still prevail today forming …
one of the early compartmentalization strategies of cells, which still prevail today forming …