Carbohydrates—namely glycans—decorate every cell in the human body and most secreted
proteins. Advances in genomics, glycoproteomics and tools from chemical biology have …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

All mammalian cells display a diverse array of glycan structures that differ from those that are
found on microbial pathogens. Siglecs are a family of sialic acid-binding immunoglobulin …

Glioblastoma (GBM) is the most aggressive form of primary brain tumor, for which effective
therapies are urgently needed. Cancer cells are capable of evading clearance by …

Herein we will review the role of glycans in the immune system. Specific topics covered
include: the glycosylation sites of IgE, IgM, IgD, IgE, IgA, and IgG; how glycans can encode …

Neutrophils are predominant immune cells that protect the human body against infections by
deploying sophisticated antimicrobial strategies including phagocytosis of bacteria and …

Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Bacteria possess an extraordinary repertoire of cell envelope glycans that have critical
physiological functions. Pathogenic bacteria have glycans that are essential for growth and …

The wide occurrence of sialic acids (Sia) in various chemical forms linked as monomers or
polymers in an outstanding position in a multitude of complex carbohydrates of animals and …