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Cyanothioacetamide: a polyfunctional reagent with broad synthetic utility
VD Dyachenko, IV Dyachenko… - Russian Chemical …, 2018 - iopscience.iop.org
The review integrates and analyzes the published data on the chemical reactivity of α-
cyanothioacetamide, a convenient starting compound for the preparation of activated …
cyanothioacetamide, a convenient starting compound for the preparation of activated …
Conjugate and regiochemical addition of aminoazoles to 2-(4-(2, 2-dicyanovinyl) phenoxy)-N-arylacetamide affording fused pyrimidines linked to phenoxy-N …
A facile, and efficient regiochemical synthesis of 7-amino [1, 2, 4] triazolo [1, 5-a] pyrimidine-
6-carbonitriles, or 4-aminobenzo [4, 5] imidazo [1, 2-a] pyrimidine-3-carbonitriles that are …
6-carbonitriles, or 4-aminobenzo [4, 5] imidazo [1, 2-a] pyrimidine-3-carbonitriles that are …
Synthesis, antimicrobial evaluation, molecular docking and theoretical calculations of novel pyrazolo [1, 5-a] pyrimidine derivatives
New fused heterocyclic compounds were synthesized starting from dimethyl terephthalate,
as a versatile precursor, via its reactions with the appropriate reagents. The structures of the …
as a versatile precursor, via its reactions with the appropriate reagents. The structures of the …
[HTML][HTML] Novel hybrid thiazoles, bis-thiazoles linked to azo-sulfamethoxazole: Synthesis, docking, and antimicrobial activity
The reaction of sulfamethoxazolehydrazonoyl chloride with thiosemicarbazones, bis-
thiosemicarbazones, or 4-amino-3-mercapto-1, 2, 4-triazole in dioxane in the presence of …
thiosemicarbazones, or 4-amino-3-mercapto-1, 2, 4-triazole in dioxane in the presence of …
Synthesis of novel mono-and bis-pyrazolylthiazole derivatives as anti-liver cancer agents through EGFR/HER2 target inhibition
Bromoacetyl-4-(2-naphthoyl)-1-phenyl-1H-pyrazole (6) was synthesized from 2-
acetylnaphthalene and was used as a new key building block for constructing the title …
acetylnaphthalene and was used as a new key building block for constructing the title …
Synthesis and antibacterial activities of novel hybrid molecules based on benzothiazole, benzimidazole, benzoxazole, and pyrimidine derivatives, each connected to …
Novel benzimidazoles, benzothiazoles, and benzoxazoles linked to N-arylacetamide were
synthesized in good yields by reacting a series of 2-oxo-2-(arylamino) ethyl 4 …
synthesized in good yields by reacting a series of 2-oxo-2-(arylamino) ethyl 4 …
Utility of 2-Chloro-N-arylacetamide and 1,1′-(Piperazine-1,4-diyl)bis(2-chloroethanone) as Versatile Precursors for Novel Mono- and Bis[thienopyridines]
A series of novel thieno [2, 3-b] pyridines linked to N-aryl carboxamides or
(carbonylphenoxy)-N-(aryl) acetamides, as well as bis (thieno [2, 3-b] pyridines) linked to …
(carbonylphenoxy)-N-(aryl) acetamides, as well as bis (thieno [2, 3-b] pyridines) linked to …
Design, synthesis, docking study, and anticancer evaluation of novel bis-thiazole derivatives linked to benzofuran or benzothiazole moieties as PI3k inhibitors and …
A molecular hybridization approach was used to construct and develop a variety of new bis-
thiazoles coupled to benzofuran or benzothiazole moieties as anticancer drugs. The target …
thiazoles coupled to benzofuran or benzothiazole moieties as anticancer drugs. The target …
Design, synthesis, DFT, TD-DFT/PCM calculations, and molecular docking studies on the anti-COVID-19, and anti-SARS activities of some new bis-thiazoles and bis …
A novel synthesis of bis (thiazoles) and bis (thiadiazole), each connected to a
thienothiophene moiety, is described. The DFT calculations support the favored synthesis of …
thienothiophene moiety, is described. The DFT calculations support the favored synthesis of …
[HTML][HTML] Acetic acid mediated for one-pot synthesis of novel pyrazolyl s-triazine derivatives for the targeted therapy of triple-negative breast tumor cells (MDA-MB-231) …
Here, we described the synthesis of novel pyrazole-s-triazine derivatives via an easy one-
pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5, 5-dimethyl …
pot procedure for the reaction of β-dicarbonyl compounds (ethylacetoacetate, 5, 5-dimethyl …