CD38 is a molecule that can act as an enzyme, with NAD-depleting and intracellular
signaling activity, or as a receptor with adhesive functions. CD38 can be found expressed …

CD8+ T cells are involved in the pathogenesis of inflammatory bowel disease (IBD), a
complex multifactorial chronic disease. Here, we present an overview of the current research …

Background & Aims Studies are needed to determine the mechanisms of mucosal
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …

Dietary interventions are potentially effective therapies for inflammatory bowel diseases
(IBDs). We tested the effect of 4-day fasting-mimicking diet (FMD) cycles on a chronic …

Chronic non-communicable diseases (NCDs) are the leading causes of work absence,
disability, and mortality worldwide. Most of these diseases are associated with low-grade …

Epigenetic alterations may provide important insights into gene-environment interaction in
inflammatory bowel disease (IBD). Here we observe epigenome-wide DNA methylation …

Background: Stress of different origin is known to alter so called “braingut axis” and
contributes to a broad array of gastrointestinal disorders including inflammatory bowel …

Distinct pathological events occur within the gastrointestinal (GI) tract of Asian macaques
with progressive simian immunodeficiency virus (SIV) infection and humans with human …

Background IL-17 and Foxp3 double-expressing (DE) CD4+ T lymphocytes are novel
crossover immune cell population, but the presence and role of these cells in human …

Nicotinamide adenine dinucleotide (NAD) acts as a cofactor in several oxidation-reduction
(redox) reactions and is a substrate for a number of nonredox enzymes. NAD is fundamental …