Sex differences in opioid and psychostimulant craving and relapse: a critical review
A widely held dogma in the preclinical addiction field is that females are more vulnerable
than males to drug craving and relapse. Here, we first review clinical studies on sex …
than males to drug craving and relapse. Here, we first review clinical studies on sex …
Cues conditioned to withdrawal and negative reinforcement: Neglected but key motivational elements driving opioid addiction
CB Pantazis, LA Gonzalez, BJ Tunstall… - Science …, 2021 - science.org
Opioid use disorder (OUD) is a debilitating disorder that affects millions of people. Neutral
cues can acquire motivational properties when paired with the positive emotional effects of …
cues can acquire motivational properties when paired with the positive emotional effects of …
Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
A two-neuron model of ventral tegmental area (VTA) opioid function classically involves VTA
GABA neuron regulation of VTA dopamine neurons via a mu-opioid receptor dependent …
GABA neuron regulation of VTA dopamine neurons via a mu-opioid receptor dependent …
Oral oxycodone self‐administration leads to features of opioid misuse in male and female mice
Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current
opioid epidemic. There are several challenges with modelling oxycodone abuse. First …
opioid epidemic. There are several challenges with modelling oxycodone abuse. First …
A buprenorphine-validated rat model of opioid use disorder optimized to study sex differences in vulnerability to relapse
Rationale Opioid use disorder (OUD) is a major epidemic in the USA. Despite evidence
indicating that OUD may be particularly severe for women, preclinical models have yet to …
indicating that OUD may be particularly severe for women, preclinical models have yet to …
Studying sex differences in rodent models of addictive behavior
Animal models of addictive behaviors are useful for uncovering neural mechanisms involved
in the development of dependence and for identifying risk factors for drug abuse. One such …
in the development of dependence and for identifying risk factors for drug abuse. One such …
Aversion-resistant fentanyl self-administration in mice
Rationale Animal models of compulsive drug use that continues despite negative
consequences can be used to investigate the neural mechanisms of addiction. However …
consequences can be used to investigate the neural mechanisms of addiction. However …
A limited access oral oxycodone paradigm produces physical dependence and mesocorticolimbic region-dependent increases in DeltaFosB expression without …
The abuse of oral formulations of prescription opioids has precipitated the current opioid
epidemic. We developed an oral oxycodone consumption model consisting of a limited …
epidemic. We developed an oral oxycodone consumption model consisting of a limited …
Chronic physical and vicarious psychosocial stress alter fentanyl consumption and nucleus accumbens Rho GTPases in male and female C57BL/6 mice
Chronic stress can increase the risk of develo** a substance use disorder in vulnerable
individuals. Numerous models have been developed to probe the underlying …
individuals. Numerous models have been developed to probe the underlying …
Opioid-induced molecular and cellular plasticity of ventral tegmental area dopamine neurons
Opioid drugs are highly valued as potent analgesics; however, there are significant risks
associated with long-term use because of their abuse liability. Opioids cause changes in …
associated with long-term use because of their abuse liability. Opioids cause changes in …