Spatial biology of cancer evolution
The natural history of cancers can be understood through the lens of evolution given that the
driving forces of cancer development are mutation and selection of fitter clones. Cancer …
driving forces of cancer development are mutation and selection of fitter clones. Cancer …
Profiling cell identity and tissue architecture with single-cell and spatial transcriptomics
Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …
Fifteen-year outcomes after monitoring, surgery, or radiotherapy for prostate cancer
Background Between 1999 and 2009 in the United Kingdom, 82,429 men between 50 and
69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer …
69 years of age received a prostate-specific antigen (PSA) test. Localized prostate cancer …
Spatial multimodal analysis of transcriptomes and metabolomes in tissues
We present a spatial omics approach that combines histology, mass spectrometry imaging
and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low …
and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low …
Slide-tags enables single-nucleus barcoding for multimodal spatial genomics
Recent technological innovations have enabled the high-throughput quantification of gene
expression and epigenetic regulation within individual cells, transforming our understanding …
expression and epigenetic regulation within individual cells, transforming our understanding …
SpatialData: an open and universal data framework for spatial omics
Spatially resolved omics technologies are transforming our understanding of biological
tissues. However, the handling of uni-and multimodal spatial omics datasets remains a …
tissues. However, the handling of uni-and multimodal spatial omics datasets remains a …
[HTML][HTML] Spatially resolved transcriptomics: a comprehensive review of their technological advances, applications, and challenges
The ability to explore life kingdoms is largely driven by innovations and breakthroughs in
technology, from the invention of the microscope 350 years ago to the recent emergence of …
technology, from the invention of the microscope 350 years ago to the recent emergence of …
Reconstruction of the tumor spatial microenvironment along the malignant-boundary-nonmalignant axis
Z Xun, X Ding, Y Zhang, B Zhang, S Lai, D Zou… - Nature …, 2023 - nature.com
Although advances in spatial transcriptomics (ST) enlarge to unveil spatial landscape of
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
tissues, it remains challenging to delineate pathology-relevant and cellular localizations …
SPACEL: deep learning-based characterization of spatial transcriptome architectures
H Xu, S Wang, M Fang, S Luo, C Chen, S Wan… - Nature …, 2023 - nature.com
Spatial transcriptomics (ST) technologies detect mRNA expression in single cells/spots
while preserving their two-dimensional (2D) spatial coordinates, allowing researchers to …
while preserving their two-dimensional (2D) spatial coordinates, allowing researchers to …
Spatial transcriptomics: technical aspects of recent developments and their applications in neuroscience and cancer research
Spatial transcriptomics is a newly emerging field that enables high‐throughput investigation
of the spatial localization of transcripts and related analyses in various applications for …
of the spatial localization of transcripts and related analyses in various applications for …