Cytokines play a pivotal role in the pathogenesis of autoimmune diseases. The precise
triggers for the breakdown of self-tolerance and the subsequent events leading to the …

T1D is an autoimmune disorder, which involves the CD4+ as well as CD8+ T-cell–mediated
destruction of β cells. Recently, another population of T cells (Th17) is found to be involved …

ABSTRACT CD8+ T cells are crucial components of immunity and play a vital role in
recovery from West Nile virus (WNV) infection. Here, we identify a previously unrecognized …

Pathogenesis of type 1 diabetes (T1D) is mediated by effector T cells and CD4 Th1 and
Th17T cells have important roles in this process. While effector function of Th1 cells is well …

Cystic fibrosis (CF) is characterized by an excessive neutrophilic inflammatory response
within the airway as a result of defective cystic fibrosis transmembrane receptor (CFTR) …

Psoriasis is a chronic skin disease associated with T helper (Th) 17-mediated inflammation.
Because CCR4 is a major chemokine receptor expressed on Th17 cells, we investigated the …

Abstract IL-17A+ CD8+ T-cells, termed Tc17 cells, have been identified at sites of
inflammation in several immune-mediated inflammatory diseases. However, the biological …

Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease characterized by the
destruction of insulin-secreting β cells upon autoreactive T cell attack. Oral administration of …

Summary Interleukin‐17 (IL‐17) is a cytokine with critical functions in multiple autoimmune
diseases. However, its roles in type I diabetes and the underlying mechanisms remain to be …

Abstract Compared with CD4+ 25+ regulatory T cells (Tregs), the mechanisms for natural,
polyclonal CD8+ 25+ Treg immune suppression have been significantly less studied. We …