The p53 protein regulates the transcription of many different genes in response to a wide
variety of stress signals. Following DNA damage, p53 regulates key processes, including …

Therapeutic irradiation of the tumor microenvironment causes differential activation of pro-
survival and pro-death pathways in malignant, stromal, endothelial and immune cells, hence …

The interferon regulatory factor (IRF) family, consisting of nine members in mammals, was
identified in the late 1980s in the context of research into the type I interferon system …

Abstract Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein–
Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I …

Tumour-suppressor genes are indispensable for the maintenance of genomic integrity.
Recently, several of these genes, including those encoding p53, PTEN, RB1 and ARF, have …

Inactivation of the most important tumour suppressor gene TP53 occurs in most, if not all,
human cancers. Loss of functional wild-type p53 is achieved via two main mechanisms …

The mononuclear phagocytes control the body homeostasis through the involvement in
resolving tissue injury and further wound healing. Indeed, local tissue microenvironmental …

Systemic lupus erythematosus (SLE) is a complex systemic autoimmune disease caused by
both genetic and environmental factors. Genome scans in families with SLE point to multiple …

p53 is a transcription factor that regulates the expression of genes involved in tumor
suppression. p53 mutations mediate tumorigenesis and occur in approximately 50% of …

Members of the interferon-regulatory factor (IRF) proteins family were originally identified as
transcriptional regulators of the Type I interferon system. Thanks to consistent advances …