One of the primary causes of attenuated or loss of efficacy of cancer chemotherapy is the
emergence of multidrug resistance (MDR). Numerous studies have been published …

With more than ten new FDA approvals since 2001, peptides are emerging as an important
therapeutic alternative to small molecules. However, unlike small molecules, peptides on the …

Without foreknowledge of the complete drug target information, development of promising
and affordable approaches for effective treatment of human diseases is challenging. Here …

Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver
disease (NAFLD) through poorly defined mechanisms. Melatonin supplementation has been …

Mitochondria play an integral role in cell death, autophagy, immunity, and inflammation. We
previously showed that Nur77, an orphan nuclear receptor, induces apoptosis by targeting …

Distinguishing true Ag-stimulated lymphocytes from bystanders activated by the
inflammatory milieu has been difficult. Nur77 is an immediate early gene whose expression …

The dynamic interplay between pro-death and pro-survival Bcl-2 family proteins is
responsible for a cell's fate. Due to the recognized relevance of this family in cancer …

Abstract B-cell lymphoma 2 (BCL2) proteins are important cell death regulators, whose main
function is to control the release of cytochrome c from mitochondria in the intrinsic apoptotic …

Introduction: Programmed cell death is well-orchestrated process regulated by multiple pro-
apoptotic and anti-apoptotic genes, particularly those of the Bcl-2 gene family. These genes …

Hybrid biomaterials are systems created from components of at least two distinct classes of
molecules, for example, synthetic macromolecules and proteins or peptide domains. The …