Reactive oxygen species (ROS) serve as cell signaling molecules generated in oxidative
metabolism and are associated with a number of human diseases. The reprogramming of …

Most chemotherapeutics elevate intracellular levels of reactive oxygen species (ROS), and
many can alter redox-homeostasis of cancer cells. It is widely accepted that the anticancer …

Reactive oxygen species (ROS), a group of highly reactive ions and molecules, are
increasingly being appreciated as powerful signaling molecules involved in the regulation of …

A central question in cell biology is how membrane-spanning receptors transmit
extracellular signals inside cells to modulate cell adhesion and motility. Focal adhesion …

Abstract Treatment of acute lung injury (ALI) and its most severe form, acute respiratory
distress syndrome (ARDS), remain unsolved problems of intensive care medicine …

The protein tyrosine phosphatase (PTP) superfamily of enzymes functions in a coordinated
manner with protein tyrosine kinases to control signalling pathways that underlie a broad …

It is well established that oxidative stress is an important cause of cell damage associated
with the initiation and progression of many diseases. Consequently, all air-living organisms …

The reactive oxygen species that are generated by mitochondrial respiration, including
hydrogen peroxide (H2O2), are potent inducers of oxidative damage and mediators of …

Reactive oxygen species (ROS) are critical for the progression of cardiovascular diseases,
inflammations and tumors. However, the mechanisms of how ROS sense metabolic stress …

Metastatic progression of cancer is associated with poor outcome, and here we examine
metabolic changes underlying this process. Although aerobic glycolysis is known to promote …