Abstract The US National Institute of Neurological Disorders and Stroke convened major
stakeholders in June 2012 to discuss how to improve the methodological reporting of animal …

Current approved drug treatments for Alzheimer disease (AD) include cholinesterase
inhibitors (donepezil, rivastigmine, galantamine) and the NMDA receptor antagonist …

Background: Synthesizing what is known about the environmental drivers of health is
instrumental to taking prevention-oriented action. Methods of research synthesis commonly …

In the human brain,≈ 30% of the energy is spent on synaptic transmission. Disappearance
of synaptic activity is the earliest consequence of cerebral ischemia. The changes of …

Progress in basic and clinical research is slowed when researchers fail to provide a
complete and accurate report of how a study was designed, executed, and the results …

Misled by animal studies and basic research? Whenever we take a closer look at the
outcome of clinical trials in a field such as, most recently, stroke or septic shock, we see how …

Systematic reviews are currently favored methods of evaluating research in order to reach
conclusions regarding medical practice. The need for such reviews is necessitated by the …

Background The “classic” endocannabinoid (eCB) system includes the cannabinoid
receptors CB1 and CB2, the eCB ligands anandamide (AEA) and 2-arachidonoylglycerol (2 …

Background: In contrast to current methods of expert-based narrative review, the Navigation
Guide is a systematic and transparent method for synthesizing environmental health …

Modern toxicology has embraced in vitro methods, and major hopes are based on the Omics
technologies and systems biology approaches they bring along (Hartung and McBride in …