Identity, structure, and function of the mitochondrial permeability transition pore: controversies, consensus, recent advances, and future directions

P Bernardi, C Gerle, AP Halestrap, EA Jonas… - Cell Death & …, 2023 - nature.com
The mitochondrial permeability transition (mPT) describes a Ca2+-dependent and
cyclophilin D (CypD)-facilitated increase of inner mitochondrial membrane permeability that …

Hormonal orchestra: mastering mitochondria's role in health and disease

E Al-Suhaimi, R AlQuwaie, R AlSaqabi, D Winarni… - Endocrine, 2024 - Springer
Mitochondria is a subcellular organelle involved in the pathogenesis of cellular stress,
immune responses, differentiation, metabolic disorders, aging, and death by regulating …

Inorganic polyphosphate and ion transport across biological membranes

Y Akosah, J Yang, E Pavlov - Biochemical Society Transactions, 2024 - portlandpress.com
Inorganic polyphosphate (polyP) is widely recognized for playing important roles and
processes involved in energy and phosphate storage, regulation of gene expression, and …

Protein folding and unfolding: proline cistrans isomerization at the c subunits of F1FO‐ATPase might open a high conductance ion channel

S Nesci - Proteins: Structure, Function, and Bioinformatics, 2022 - Wiley Online Library
The c subunits, which constitute the c‐ring apparatus of the F1FO‐ATPase, could be the
main components of the mitochondrial permeability transition pore (mPTP). The well‐known …

Cyclophilin D in Mitochondrial Dysfunction: A Key Player in Neurodegeneration?

G Coluccino, VP Muraca, A Corazza, G Lippe - Biomolecules, 2023 - mdpi.com
Mitochondrial dysfunction plays a pivotal role in numerous complex diseases.
Understanding the molecular mechanisms by which the “powerhouse of the cell” turns into …

[HTML][HTML] A hypothetical mechanism capable to reflect the features of the mitochondrial permeability transition pore channel

AG Dimitrov - Advances in Redox Research, 2024 - Elsevier
Mitochondrial permeability transition pore (mPTP) channel plays a central role in cell death
because it mediates the effect of a sudden large opening of the inner mitochondrial …

[HTML][HTML] Similarities between fibroblasts and cardiomyocytes in the study of the permeability transition pore

G Morciano, G Pedriali, E Mikus… - European Journal of …, 2022 - ncbi.nlm.nih.gov
The investigation of biological processes involved in cardiovascular diseases and the study
of new cardioprotective strategies and therapeutic targets in human specimens are …

[ZITATION][C] The Contribution of Mitochondrial Calcium Flux to Permeability Transition Pore Opening

F Ullah - 2022 - Quaid i Azam University, Islamabad