DYRK1A and cognition: A lifelong relationship
ML Arbones, A Thomazeau… - Pharmacology & …, 2019 - Elsevier
The dosage of the serine threonine kinase DYRK1A is critical in the central nervous system
(CNS) during development and aging. This review analyzes the functions of this kinase by …
(CNS) during development and aging. This review analyzes the functions of this kinase by …
The chromosome 21 kinase DYRK1A: emerging roles in cancer biology and potential as a therapeutic target
M Rammohan, E Harris, RS Bhansali, E Zhao, LS Li… - Oncogene, 2022 - nature.com
Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) is a
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …
serine/threonine kinase that belongs to the DYRK family of proteins, a subgroup of the …
Silmitasertib (CX-4945), a clinically used CK2-kinase inhibitor with additional effects on GSK3β and DYRK1A kinases: A structural perspective
P Grygier, K Pustelny, J Nowak, P Golik… - Journal of medicinal …, 2023 - ACS Publications
A clinical casein kinase 2 inhibitor, CX-4945 (silmitasertib), shows significant affinity toward
the DYRK1A and GSK3β kinases, involved in down syndrome phenotypes, Alzheimer's …
the DYRK1A and GSK3β kinases, involved in down syndrome phenotypes, Alzheimer's …
DYRK1A regulates B cell acute lymphoblastic leukemia through phosphorylation of FOXO1 and STAT3
RS Bhansali, M Rammohan, P Lee… - The Journal of …, 2021 - Am Soc Clin Investig
DYRK1A is a serine/threonine kinase encoded on human chromosome 21 (HSA21) that has
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …
been implicated in several pathologies of Down syndrome (DS), including cognitive deficits …
Increased dosage of DYRK1A leads to congenital heart defects in a mouse model of Down syndrome
E Lana-Elola, R Aoidi, M Llorian, D Gibbins… - Science translational …, 2024 - science.org
Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21). DS is a gene
dosage disorder that results in multiple phenotypes including congenital heart defects. This …
dosage disorder that results in multiple phenotypes including congenital heart defects. This …
RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence
A Galloway, A Saveliev, S Łukasiak, DJ Hodson… - Science, 2016 - science.org
Progression through the stages of lymphocyte development requires coordination of the cell
cycle. Such coordination ensures genomic integrity while cells somatically rearrange their …
cycle. Such coordination ensures genomic integrity while cells somatically rearrange their …
The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
Human beta cell regenerative drug therapy for diabetes: past achievements and future challenges
A quantitative deficiency of normally functioning insulin-producing pancreatic beta cells is a
major contributor to all common forms of diabetes. This is the underlying premise for …
major contributor to all common forms of diabetes. This is the underlying premise for …
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
The last decade has revealed new roles for Cullin-RING ubiquitin ligases (CRLs) in a myriad
of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF …
of cellular processes, including cell cycle progression. In addition to CRL1, also named SCF …
DYRK1A promotes viral entry of highly pathogenic human coronaviruses in a kinase-independent manner
Identifying host genes essential for Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …
(SARS-CoV-2) has the potential to reveal novel drug targets and further our understanding …