Emerging therapies for Angelman syndrome, a severe neurodevelopmental disorder, are
focused on restoring UBE3A gene expression in the brain. Further therapeutic opportunities …

Ubiquitination regulates a myriad of eukaryotic signaling cascades by modifying substrate
proteins, thereby determining their functions and fates. In this perspective, we discuss …

Angelman syndrome (AS) is a neurogenetic disorder caused by the loss of ubiquitin ligase
E3A (UBE3A) gene expression in the brain. The UBE3A gene is paternally imprinted in brain …

Ubiquitination is one of the most conserved post-translational modifications and together
with mRNA translation contributes to cellular protein homeostasis (proteostasis). Temporal …

Background The innate immune system serves as the host's first line of defense against
invading pathogens. Stimulator of interferon genes (STING) is a key component of this …

Transketolase (TKT) is an essential thiamine diphosphate (ThDP)-dependent enzyme of the
non-oxidative branch of the pentose phosphate pathway, with the glucose-6P flux through …

The UBE3A gene, located in the chromosomal region 15q11-13, is subject to neuron-
specific genomic imprinting and it plays a critical role in brain development. Genetic defects …

The primary goal of this study is to highlight human behavior toward green consumers,
which helps to improve the social environment. In this regard, digital transformation is taken …

The ubiquitin (Ub) ligase E6AP, which is encoded by the UBE3A gene, has been associated
with several human diseases including cervical cancer and Angelman syndrome, a …

Lamins A/C (encoded by LMNA gene) can lead to dilated cardiomyopathy (DCM). This pilot
study sought to explore the postgenomic phenotype of end-stage lamin heart disease …