Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Ferroptosis, a cell death process driven by iron-dependent phospholipid peroxidation, has
been implicated in various diseases. There are two major surveillance mechanisms to …
been implicated in various diseases. There are two major surveillance mechanisms to …
Understanding sorafenib-induced ferroptosis and resistance mechanisms: implications for cancer therapy
Q Li, K Chen, T Zhang, D Jiang, L Chen, J Jiang… - European Journal of …, 2023 - Elsevier
Sorafenib is an important first-line treatment option for liver cancer due to its well-
characterized safety profile. While novel first-line drugs may have better efficacy than …
characterized safety profile. While novel first-line drugs may have better efficacy than …
[HTML][HTML] Lipid peroxidation increases membrane tension, Piezo1 gating, and cation permeability to execute ferroptosis
The ongoing metabolic and microbicidal pathways that support and protect cellular life
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …
generate potentially damaging reactive oxygen species (ROS). To counteract damage, cells …
[HTML][HTML] Identification of hyperoxidized PRDX3 as a ferroptosis marker reveals ferroptotic damage in chronic liver diseases
Ferroptosis, a regulated cell death pathway driven by accumulation of phospholipid
peroxides, has been challenging to identify in physiological conditions owing to the lack of a …
peroxides, has been challenging to identify in physiological conditions owing to the lack of a …
Sensitization of cancer cells to ferroptosis coincident with cell cycle arrest
Ferroptosis is a non-apoptotic form of cell death that can be triggered by inhibiting the
system xc− cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione …
system xc− cystine/glutamate antiporter or the phospholipid hydroperoxidase glutathione …
OPA1 promotes ferroptosis by augmenting mitochondrial ROS and suppressing an integrated stress response
Ferroptosis, an iron-dependent form of nonapoptotic cell death mediated by lipid
peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular …
peroxidation, has been implicated in the pathogenesis of multiple diseases. Subcellular …
Ferroptosis inhibition by oleic acid mitigates iron-overload-induced injury
J Mann, E Reznik, M Santer, MA Fongheiser… - Cell chemical …, 2024 - cell.com
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity
whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis …
whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis …
[HTML][HTML] Ferroptosis: A flexible constellation of related biochemical mechanisms
It is common to think about and depict biological processes as being governed by fixed
pathways with specific components interconnected by concrete positive and negative …
pathways with specific components interconnected by concrete positive and negative …
Moderate intensity of treadmill exercise rescues TBI-induced ferroptosis, neurodegeneration, and cognitive impairments via suppressing STING pathway
J Chen, T Zhu, D Yu, B Yan, Y Zhang, J **… - Molecular …, 2023 - Springer
Traumatic brain injury (TBI) is a universal leading cause of long-term neurological disability
and causes a huge burden to an ever-growing population. Moderate intensity of treadmill …
and causes a huge burden to an ever-growing population. Moderate intensity of treadmill …
Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking
KH Sokol, CJ Lee, TJ Rogers, A Waldhart, AE Ellis… - Cell Chemical …, 2024 - cell.com
Ferroptosis is a form of cell death caused by lipid peroxidation that is emerging as a target
for cancer therapy, highlighting the need to identify factors that govern ferroptosis …
for cancer therapy, highlighting the need to identify factors that govern ferroptosis …